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  Electrophysiological characterization of the hyperdirect pathway and its functional relevance for subthalamic deep brain stimulation

Bahners, B. H., Waterstraat, G., Kannenberg, S., Curio, G., Schnitzler, A., Nikulin, V. V., et al. (2022). Electrophysiological characterization of the hyperdirect pathway and its functional relevance for subthalamic deep brain stimulation. Experimental Neurology, 114031. doi:10.1016/j.expneurol.2022.114031.

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 Creators:
Bahners, Bahne Hendrik1, Author
Waterstraat, Gunnar2, Author
Kannenberg, Silja1, Author
Curio, Gabriel2, 3, Author
Schnitzler, Alfons1, 4, Author
Nikulin, Vadim V.5, Author              
Florin, Esther1, Author
Affiliations:
1Institute for Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Germany, ou_persistent22              
2Neurophysics Group, Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
3Bernstein Center for Computational Neuroscience, Berlin, Germany, ou_persistent22              
4Centre for Movement Disorders and Neuromodulation, Department of Neurology, Institute for Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Germany, ou_persistent22              
5Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: High frequency oscillations; Stimulation evoked responses; Antidromic activation; Signal-to-noise ratio
 Abstract: The subthalamic nucleus (STN) receives input from various cortical areas via hyperdirect pathway (HDP) which bypasses the basal-ganglia loop. Recently, the HDP has gained increasing interest, because of its relevance for STN deep brain stimulation (DBS). To understand the HDP's role cortical responses evoked by STN-DBS have been investigated. These responses have short (<2 ms), medium (2–15 ms), and long (20–70 ms) latencies. Medium-latency responses are supposed to represent antidromic cortical activations via HDP. Together with long-latency responses the medium responses can potentially be used as biomarker of DBS efficacy as well as side effects. We here propose that the activation sequence of the cortical evoked responses can be conceptualized as high frequency oscillations (HFO) for signal analysis. HFO might therefore serve as marker for antidromic activation. Using existing knowledge on HFO recordings, this approach allows data analyses and physiological modeling to advance the pathophysiological understanding of cortical DBS-evoked high-frequency activity.

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Language(s): eng - English
 Dates: 2022-02-012021-03-312022-02-282022-03-02
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.expneurol.2022.114031
 Degree: -

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Title: Experimental Neurology
  Other : Exp. Neurol.
Source Genre: Journal
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Publ. Info: San Diego, CA : Academic Press
Pages: - Volume / Issue: - Sequence Number: 114031 Start / End Page: - Identifier: ISSN: 0014-4886
CoNE: https://pure.mpg.de/cone/journals/resource/991042743109584