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  Regulation of dopaminergic activity in early Parkinson's disease

Tedroff, J., Ekesbo, A., Rydin, E., Långström, B., & Hagberg, G. (1999). Regulation of dopaminergic activity in early Parkinson's disease. Annals of Neurology, 46(3), 359-365. doi:10.1002/1531-8249(199909)46:3<359:AID-ANA11>3.0.CO;2-G.

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Tedroff, J, Author
Ekesbo, A, Author
Rydin, E, Author
Långström, B, Author
Hagberg, G1, Author              
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1External Organizations, ou_persistent22              

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 Abstract: Parkinson's disease (PD) is characterized by an uneven and progressive loss of nigrostriatal dopaminergic neurons. It is hypothesized that the physiological basis for the therapeutic response in early stages of PD is the ability for the partially and unevenly denervated dopaminergic system to restore and normalize dopaminergic influence in functionally segregated subregions of the basal ganglia. To investigate this hypothesis, patients with early and uncomplicated PD were investigated with positron emission tomography by using a two-tracer protocol yielding a measure of dopamine transporter–corrected dopamine synthesis capacity. Compared with controls, patients with PD exhibited a considerable increase in dopamine transporter–corrected dopamine synthesis capacity. The increase showed an inverse dependence on the structural integrity in as much as the highest rate was measured in the most denervated region, the dorsal part of putamen (198% of control value). A therapeutic challenge with antiparkinsonian medication state-dependently decreased dopaminergic activity. Thus, it is demonstrated that dopaminergic degeneration in PD is accompanied by a conspicuous acceleration of presynaptic dopaminergic activity, which is state-dependently down-regulated by dopaminomimetic treatment. It is suggested that homeostatic mechanisms acting to maintain congruity within the dopaminergic system are functionally intact in early PD.

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 Dates: 1999-09
 Publication Status: Published in print
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Title: Annals of Neurology
Source Genre: Journal
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Publ. Info: Boston : American Neurological Association
Pages: - Volume / Issue: 46 (3) Sequence Number: - Start / End Page: 359 - 365 Identifier: ISSN: 0364-5134
CoNE: https://pure.mpg.de/cone/journals/resource/954925523748