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  Increased synthesis of dopamine in prefrontal cortex and striatum in drug-naive schizophrenic patients studied by use of 11C-labelled L-dopamine and positron emission tomography

Lindström, L., Gefvert, O., Hagberg, G., Hagström, P., Lundberg, T., Bergström, M., et al. (1998). Increased synthesis of dopamine in prefrontal cortex and striatum in drug-naive schizophrenic patients studied by use of 11C-labelled L-dopamine and positron emission tomography. Nordic Journal of Psychiatry, 52(2), 102. doi:10.1080/08039489850138987.

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Lindström, LH, Author
Gefvert, O, Author
Hagberg, G1, Author           
Hagström, P, Author
Lundberg, T, Author
Bergström, M, Author
Hartvig, P, Author
Langström, B, Author
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1External Organizations, ou_persistent22              

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 Abstract: The present study was design to test the hypothesis of a deviant dopaminergic activity in schizophrenia by using the positron emission tomography (PET) technique (GE 2048-15B Plus camera) and 11C-labelled L-DOPA as the tracer, which enables calculation of the rate of synthesis (‘utilization’) of dopamine in different brain regions. Twelve first-admitted and never-treated patients with a DSM-IV diagnosis of schizophrenia (10 men and 2 women) were included. Their mean age was 31.6 years. Controls were 10 healthy volunteers (8 male and 2 female) with a mean age of 33 years. Scanning began immediately after injection of 11C-L-DOPA and continued for 60 min. A patlak plot was calculated for each individual, giving the K3 value, which indirectly reflects the enzymatic utilization of L-DOPA and indirectly the synthesis rate for dopamine. The data showed no lateralization for any brain region tested, either in controls or in schizophrenic patients. However, when compared with healthy controls, a significantly increased synthesis of dopamine was found in the putamen (K3, 1.75 versus 1.59, P = 0.01) and in the caudatus (K3, 1.72 versus 1.50, P=0.002). Further, a significantly increased K3 was also seen in the medial prefrontal cortex in schizophrenic patients (K3, 0.84 versus 0.70, P=0.014). The present results indicate an increased synthesis of dopamine in certain brain areas, most interestingly in the frontal lobe, in schizophrenia.

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 Dates: 2009-071998-04
 Publication Status: Published in print
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 Identifiers: DOI: 10.1080/08039489850138987
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Title: 38th Annual Meeting of the Scandinavian Society for Psychopharmacology
Place of Event: Kopenhagen, Denmark
Start-/End Date: 1988-04-22 - 1988-04-24

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Title: Nordic Journal of Psychiatry
  Other : Nord. J. Psychiatr.
Source Genre: Journal
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Publ. Info: Oslo : Scandinavian University Press
Pages: - Volume / Issue: 52 (2) Sequence Number: - Start / End Page: 102 Identifier: ISSN: 0803-9488
CoNE: https://pure.mpg.de/cone/journals/resource/110978979589019