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  The age-dependent association between vascular risk factors and depressed mood

Blöchl, M., Schaare, H. L., Kunzmann, U., & Nestler, S. (2021). The age-dependent association between vascular risk factors and depressed mood. Journals of Gerontology: Series B, Psychological Sciences and Social Sciences, 77(2), 284-294. doi:10.1093/geronb/gbab063.

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 Creators:
Blöchl, Maria1, 2, Author              
Schaare, Herma Lina3, 4, Author              
Kunzmann, Ute5, Author
Nestler, Steffen1, Author
Affiliations:
1Institute for Psychology, Münster University, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264              
4Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
5Institute of Psychology, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Aging; Cardiovascular health; Depression; Latent growth models; Vascular depression hypothesis
 Abstract: Objectives: Cumulative burden of vascular risk factors (VRFs) has been linked to an increased risk of depressed mood. However, the role of age in this association is still unclear. Here, we investigated whether VRF burden is associated with levels and changes in depressed mood and whether these associations become stronger or weaker from mid- to later life. Method: We used longitudinal data from 5,689 participants (52-89 years) of the English Longitudinal Study of Ageing. A composite score incorporated the presence of 5 VRFs: hypertension, diabetes, smoking, obesity, and hypercholesterolemia. Second-order latent growth models were used to test whether levels and changes of depressed mood differed as a function of baseline VRF burden, and whether these associations were moderated by age. Results: Baseline VRF burden showed a small association with higher levels of depressed mood (estimate = 0.081; 95% CI: 0.024, 0.138, p = .005). This association varied with age, such that it was stronger in midlife compared to later life (estimate = -0.007; 95% CI: -0.013, -0.002, p = .017). There was no evidence that VRF burden was associated with changes in depressed mood. Discussion: Our findings suggest that VRF burden in midlife, but less so in later life, predicts individual differences in depressed mood. These findings are consistent with reports on the importance of midlife VRFs and support the idea that promotion of vascular health in this age group or earlier in life may be critical to maintain mental health across adulthood.

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Language(s): eng - English
 Dates: 2021-03-242020-10-262021-06-032021-06-03
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1093/geronb/gbab063
PMID: 34080633
PMC: PMC8824621
 Degree: -

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Title: Journals of Gerontology: Series B, Psychological Sciences and Social Sciences
  Other : Journal of Gerontology: Psychological Sciences
  Abbreviation : J Gerontol B Psychol Sci Soc Sci
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington, DC : Gerontological Society of America
Pages: - Volume / Issue: 77 (2) Sequence Number: - Start / End Page: 284 - 294 Identifier: ISSN: 1079-5014
CoNE: https://pure.mpg.de/cone/journals/resource/954926946763