English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  DNA methylation signatures reveal that distinct combinations of transcription factors specify human immune cell epigenetic identity

Roy, R., Ramamoorthy, S., Shapiro, B. D., Kaileh, M., Hernandez, D., Sarantopoulou, D., et al. (2021). DNA methylation signatures reveal that distinct combinations of transcription factors specify human immune cell epigenetic identity. Immunity, 54, 2465-2480. doi:10.1016/j.immuni.2021.10.001.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files
hide Files
:
Roy et al. 2021.pdf (Publisher version), 7MB
 
File Permalink:
-
Name:
Roy et al. 2021.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute of Immunobiology and Epigenetics, MFIB; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Roy, Roshni1, Author
Ramamoorthy, Senthilkumar2, Author
Shapiro, Benjamin D.1, Author
Kaileh, Mary1, Author
Hernandez, Dena1, Author
Sarantopoulou, Dimitra1, Author
Arepalli, Sampath1, Author
Boller, Sören2, Author
Singh, Amit1, Author
Bektas, Arsun1, Author
Kim, Jaekwan1, Author
Moore, Ann Zenobia1, Author
Tanaka, Toshiko1, Author
McKelvey, Julia1, Author
Zukley, Linda1, Author
Nguyen, Cuong1, Author
Wallace, Tonya1, Author
Dunn, Christopher1, Author
Wersto, Robert1, Author
Wood, William1, Author
Piao, Yulan1, AuthorBecker, Kevin G.1, AuthorColetta, Christopher1, AuthorDe, Supriyo1, AuthorSen, Jyoti Misra1, AuthorBattle, Alexis1, AuthorWeng, Nan-ping1, AuthorGrosschedl, Rudolf2, Author              Ferrucci, Luigi1, AuthorSen, Ranjan1, Author more..
Affiliations:
1External Organizations, ou_persistent22              
2Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243641              

Content

show
hide
Free keywords: -
 Abstract: Epigenetic reprogramming underlies specification of immune cell lineages, but patterns that uniquely define immune cell types and the mechanisms by which they are established remain unclear. Here, we identified lineage-specific DNA methylation signatures of six immune cell types from human peripheral blood and determined their relationship to other epigenetic and transcriptomic patterns. Sites of lineage-specific hypomethylation were associated with distinct combinations of transcription factors in each cell type. By contrast, sites of lineage-specific hypermethylation were restricted mostly to adaptive immune cells. PU.1 binding sites were associated with lineage-specific hypo- and hypermethylation in different cell types, suggesting that it regulates DNA methylation in a context-dependent manner. These observations indicate that innate and adaptive immune lineages are specified by distinct epigenetic mechanisms via combinatorial and context-dependent use of key transcription factors. The cell-specific epigenomics and transcriptional patterns identified serve as a foundation for future studies on immune dysregulation in diseases and aging.

Details

show
hide
Language(s): eng - English
 Dates: 2021-10-262021-11-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.immuni.2021.10.001
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Immunity
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 54 Sequence Number: - Start / End Page: 2465 - 2480 Identifier: ISSN: 1074-7613
CoNE: https://pure.mpg.de/cone/journals/resource/954925604783