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  What makes a megaplasmid?

Hall, J. P. J., Botelho, J., Cazares, A., & Baltrus, D. A. (2022). What makes a megaplasmid? Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences, 377(1842): 20200472. doi:10.1098/rstb.2020.0472.

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rstb.2020.0472.pdf (Publisher version), 805KB
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 Creators:
Hall, James P. J., Author
Botelho, João1, Author           
Cazares, Adrian, Author
Baltrus, David A., Author
Affiliations:
1Max Planck Fellow Group Antibiotic Resistance Evolution, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2600692              

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Free keywords: plasmid, megaplasmid, mobile geneticelement, genome evolution, horizontalgene transfer, pangenome
 Abstract: Naturally occurring plasmids come in different sizes. The smallest are less than a kilobase of DNA, while the largest can be over three orders of magnitude larger. Historically, research has tended to focus on smaller plasmids that are usually easier to isolate, manipulate and sequence, but with improved genome assemblies made possible by long-read sequencing, there is increased appreciation that very large plasmids—known as megaplasmids—are widespread, diverse, complex, and often encode key traits in the biology of their host microorganisms. Why are megaplasmids so big? What other features come with large plasmid size that could affect bacterial ecology and evolution? Are megaplasmids 'just' big plasmids, or do they have distinct characteristics? In this perspective, we reflect on the distribution, diversity, biology, and gene content of megaplasmids, providing an overview to these large, yet often overlooked, mobile genetic elements. This article is part of the theme issue ‘The secret lives of microbial mobile genetic elements’.

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Language(s): eng - English
 Dates: 2021-05-192021-10-062021-11-292022-01
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1098/rstb.2020.0472
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Title: Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences
  Other : Philosophical Transactions B
  Abbreviation : Phil. Trans. R. Soc. B
Source Genre: Journal
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Publ. Info: London : Royal Society
Pages: - Volume / Issue: 377 (1842) Sequence Number: 20200472 Start / End Page: - Identifier: ISSN: 0962-8436
CoNE: https://pure.mpg.de/cone/journals/resource/963017382021_1