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  How to resist Notch-targeted T-leukemia therapy: Lineage- and MYC enhancer switch

Bayer, M., & Grosschedl, R. (2022). How to resist Notch-targeted T-leukemia therapy: Lineage- and MYC enhancer switch. Molecular Cell, 82, 884-886. doi:10.1016/j.molcel.2022.02.015.

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Bayer Grosschedl 2022.pdf (Publisher version), 627KB
 
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Bayer, Marc1, Author
Grosschedl, Rudolf1, Author              
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1Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243641              

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 Abstract: Gain-of-function NOTCH1 mutations drive oncogenic MYC expression in T-ALL cells. Zhou et al. (2022) reveal that Notch-targeted therapy-resistant T-ALL cells activate EBF1, which promotes a T-to-B lineage shift and maintains oncogenic MYC expression in the absence of Notch signaling.

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Language(s): eng - English
 Dates: 2022-03-032022-03-03
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.molcel.2022.02.015
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Title: Molecular Cell
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 82 Sequence Number: - Start / End Page: 884 - 886 Identifier: ISSN: 1097-2765
CoNE: https://pure.mpg.de/cone/journals/resource/954925610929