English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
 Local TagsRelease HistoryDetailsSummary
  How to resist Notch-targeted T-leukemia therapy: Lineage- and MYC enhancer switch

Bayer, M., & Grosschedl, R. (2022). How to resist Notch-targeted T-leukemia therapy: Lineage- and MYC enhancer switch. Molecular Cell, 82, 884-886. doi:10.1016/j.molcel.2022.02.015.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/21.11116/0000-000A-1806-5 Version Permalink: https://hdl.handle.net/21.11116/0000-000A-1807-4
Genre: Journal Article

Files

show Files
hide Files
:
Bayer Grosschedl 2022.pdf (Publisher version), 627KB
 
File Permalink:
-
Name:
Bayer Grosschedl 2022.pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute of Immunobiology and Epigenetics, MFIB; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Locator:
https://www.sciencedirect.com/science/article/abs/pii/S1097276522001381 (Publisher version)
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Bayer, Marc1, Author
Grosschedl, Rudolf1, Author           
Affiliations:
1Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243641              

Content

show
hide
Free keywords: -
 Abstract: Gain-of-function NOTCH1 mutations drive oncogenic MYC expression in T-ALL cells. Zhou et al. (2022) reveal that Notch-targeted therapy-resistant T-ALL cells activate EBF1, which promotes a T-to-B lineage shift and maintains oncogenic MYC expression in the absence of Notch signaling.

Details

show
hide
Language(s): eng - English
 Dates: 2022-03-032022-03-03
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.molcel.2022.02.015
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Molecular Cell
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 82 Sequence Number: - Start / End Page: 884 - 886 Identifier: ISSN: 1097-2765
CoNE: https://pure.mpg.de/cone/journals/resource/954925610929