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  Symptom-severity-related brain connectivity alterations in functional movement disorders

Mueller, K., Růžička, F., Slovák, M., Forejtová, Z., Dušek, P., Dušek, P., et al. (2022). Symptom-severity-related brain connectivity alterations in functional movement disorders. NeuroImage: Clinical, 34: 102981. doi:10.1016/j.nicl.2022.102981.

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karstenm_FMD.pdf (Publisher version), 5MB
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2022-03-03
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 Creators:
Mueller, Karsten1, Author              
Růžička, Filip2, Author
Slovák, Matěj2, Author
Forejtová, Zuzana2, Author
Dušek, Petr2, Author
Dušek, Pavel2, Author
Jech, Robert2, Author
Serranová, Tereza2, Author
Affiliations:
1Method and Development Group Neural Data Science and Statistical Computing, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3282987              
2Department of Neurology, Charles University, Prague, Czech Republic, ou_persistent22              

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Free keywords: Functional movement disorders; Motor conversion disorder; Functional weakness; Brain connectivity; Functional connectivity; Functional magnetic resonance imaging; Temporoparietal junction; Precuneus
 Abstract: Background Functional movement disorders, a common cause of neurological disabilities, can occur with heterogeneous motor manifestations including functional weakness. However, the underlying mechanisms related to brain function and connectivity are unknown. Objective To identify brain connectivity alterations related to functional weakness we assessed network centrality changes in a group of patients with heterogeneous motor manifestations using task-free functional MRI in combination with different network centrality approaches. Methods Task-free functional MRI was performed in 48 patients with heterogeneous motor manifestations including 28 patients showing functional weakness and 65 age- and sex-matched healthy controls. Functional connectivity differences were assessed using different network centrality approaches, i.e. global correlation, eigenvector centrality, and intrinsic connectivity. Motor symptom severity was assessed using The Simplified Functional Movement Disorders Rating Scale and correlated with network centrality. Results Comparing patients with and without functional weakness showed significant network centrality differences in the left temporoparietal junction and precuneus. Patients with functional weakness showed increased centrality in the same anatomical regions when comparing functional weakness with healthy controls. Moreover, in the same regions, patients with functional weakness showed a positive correlation between motor symptom severity and network centrality. This correlation was shown to be specific to functional weakness with an interaction analysis, confirming a significant difference between patients with and without functional weakness. Conclusions We identified the temporoparietal junction and precuneus as key regions involved in brain connectivity alterations related to functional weakness. We propose that both regions may be promising targets for phenotype-specific non-invasive brain stimulation.

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Language(s): eng - English
 Dates: 2022-03-012021-11-102022-03-022022-03-03
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.nicl.2022.102981
 Degree: -

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Title: NeuroImage: Clinical
Source Genre: Journal
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Publ. Info: Elsevier
Pages: - Volume / Issue: 34 Sequence Number: 102981 Start / End Page: - Identifier: ISSN: 2213-1582
CoNE: https://pure.mpg.de/cone/journals/resource/2213-1582