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  Associations between life-course socioeconomic conditions and the pace of aging

Schrempft, S., Belsky, D. W., Draganski, B., Kliegel, M., Vollenweider, P., Marques-Vidal, P., et al. (2021). Associations between life-course socioeconomic conditions and the pace of aging. Journals of Gerontology: Series A, Biological Sciences and Medical Sciences. doi:10.1093/gerona/glab383.

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 Creators:
Schrempft, Stephanie1, Author
Belsky, Daniel W2, 3, Author
Draganski, Bogdan4, 5, Author              
Kliegel, Matthias6, 7, 8, Author
Vollenweider, Peter9, Author
Marques-Vidal, Pedro9, Author
Preisig, Martin10, Author
Stringhini, Silvia1, 11, 12, Author
Affiliations:
1Division of Primary Care, University Hospital of Geneva, Switzerland, ou_persistent22              
2Department of Epidemiology, Mailman School of Public Health, Columbia University in the City of New York, NY, USA, ou_persistent22              
3Robert N. Butler Columbia Aging Center, Columbia University in the City of New York, NY, USA , ou_persistent22              
4Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
5Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
6Swiss National Centre of Competence in Research, University of Lausanne, Switzerland, ou_persistent22              
7Centre for the Interdisciplinary Study of Gerontology and Vulnerability (CIGEV), University of Geneva, Switzerland, ou_persistent22              
8Department of Psychology, University of Geneva, Switzerland, ou_persistent22              
9Department of Medicine, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
10Department of Psychiatry, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
11Department of Health and Community Medicine, University of Geneva, Switzerland, ou_persistent22              
12Center for Primary Care and Public Health, University of Lausanne, Switzerland, ou_persistent22              

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Free keywords: Biological age; Biomarkers; Physiological decline; Social inequalities; Social mobility
 Abstract: Background: Socioeconomic disadvantage is a well-established predictor of morbidity and mortality, and is thought to accelerate the aging process. This study examined associations between life course socioeconomic conditions and the Pace of Aging, a longitudinal measure of age-related physiological decline. Methods: Data were drawn from a Swiss population-based cohort of individuals originally recruited between 2003 and 2006, and followed up for 11 years (2834 women, 2475 men aged 35 - 75 years (mean 52)). Pace of Aging was measured using three repeated assessments of 12 biomarkers reflecting multiple body systems. Analysis tested associations of socioeconomic conditions with physiological status at baseline and with the Pace of Aging. Results: Participants with more life course socioeconomic disadvantage were physiologically older at baseline and experienced faster Pace of Aging. Effect-sizes (β) for associations of childhood socioeconomic disadvantage with baseline physiological status ranged from 0.1-0.2; for adulthood socioeconomic disadvantage, effect-sizes ranged from 0.2-0.3. Effect-sizes were smaller for associations with the Pace of Aging (< 0.05 for childhood disadvantage, 0.05-0.1 for adulthood disadvantage). Those who experienced disadvantaged socioeconomic conditions from childhood to adulthood aged 10% faster over the 11 years of follow-up as compared with those who experienced consistently advantaged socioeconomic conditions. Covariate adjustment for health behaviors attenuated associations, but most remained statistically significant. Conclusions: Socioeconomic inequalities contribute to a faster Pace of Aging, partly through differences in health behaviors. Intervention to slow aging in at risk individuals is needed by midlife, before aetiology of aging-related diseases become established.

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Language(s): eng - English
 Dates: 2021-12-24
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1093/gerona/glab383
Other: online ahead of print
PMID: 34951641
 Degree: -

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Title: Journals of Gerontology: Series A, Biological Sciences and Medical Sciences
  Other : J. Gerontol. / Series A
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington, DC : Gerontological Society of America
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1079-5006
CoNE: https://pure.mpg.de/cone/journals/resource/954925606828