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  Multi-parameter quantitative mapping of R1, R2*, PD, and MTsat is reproducible when accelerated with Compressed SENSE

Berg, R. C., Leutritz, T., Weiskopf, N., & Preibisch, C. (2022). Multi-parameter quantitative mapping of R1, R2*, PD, and MTsat is reproducible when accelerated with Compressed SENSE. NeuroImage, 253: 119092. doi:10.1016/j.neuroimage.2022.119092.

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 Creators:
Berg, Ronja C.1, 2, Author
Leutritz, Tobias3, Author              
Weiskopf, Nikolaus3, 4, Author              
Preibisch, Christine1, 2, 5, Author
Affiliations:
1Department of Diagnostic and Interventional Neuroradiology, School of Medicine, TU Munich, Germany, ou_persistent22              
2Department of Neurology, School of Medicine, TU Munich, Germany, ou_persistent22              
3Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
4Felix Bloch Institute for Solid State Physics, University of Leipzig, Germany, ou_persistent22              
5Neuroimaging Center (TUM-NIC), TU Munich, Germany, ou_persistent22              

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Free keywords: Multi-parameter mapping; Quantitative MRI; Compressed SENSE; Imaging acceleration; Reproducibility
 Abstract: Multi-parameter mapping (MPM) magnetic resonance imaging (MRI) provides quantitative estimates of the longitudinal and effective transverse relaxation rates R1 and R2*, proton density (PD), and magnetization transfer saturation (MTsat). Thereby, MPM enables better comparability across sites and time than conventional weighted MRI. However, for MPM, several contrasts must be acquired, resulting in prolonged measurement durations and thus preventing MPM's application in clinical routines. State-of-the-art imaging acceleration techniques such as Compressed SENSE (CS), a combination of compressed sensing and sensitivity encoding, can be used to reduce the scan time of MPM. However, the accuracy and precision of the resulting quantitative parameter maps have not been systematically evaluated. In this study, we therefore investigated the effect of CS acceleration on the fidelity and reproducibility of MPM acquisitions. In five healthy volunteers and in a phantom, we compared MPM metrics acquired without imaging acceleration, with the standard acceleration (SENSE factor 2.5), and with Compressed SENSE with acceleration factors 4 and 6 using a 32-channel head coil. We evaluated the reproducibility and repeatability of accelerated MPM using data from three scan sessions in gray and white matter volumes-of-interest (VOIs). Accelerated MPM provided precise and accurate quantitative parameter maps. For most parameters, the results of the CS-accelerated protocols correlated more strongly with the non-accelerated protocol than the standard SENSE-accelerated protocols. Furthermore, for most VOIs and contrasts, coefficients of variation were lower when calculated from data acquired with different imaging accelerations within a single scan session than from data acquired in different scan sessions. These results suggest that MPM with Compressed SENSE acceleration factors up to at least 6 yields reproducible quantitative parameter maps that are highly comparable to those acquired without imaging acceleration. Compressed SENSE can thus be used to considerably reduce the scan duration of R1, R2*, PD, and MTsat mapping, and is highly promising for clinical applications of MPM.

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Language(s): eng - English
 Dates: 2022-03-072021-10-122022-03-082022-03-112022-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.neuroimage.2022.119092
Other: online ahead of print
PMID: 35288281
 Degree: -

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Project name : -
Grant ID : PR 1039/6-1
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : -
Grant ID : 681094
Funding program : Horizon 2020
Funding organization : European Union
Project name : -
Grant ID : 616905
Funding program : -
Funding organization : European Research Council
Project name : -
Grant ID : 01EW1711A & B
Funding program : -
Funding organization : Bundesministerium für Bildung und Forschung (BMBF)

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Title: NeuroImage
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 253 Sequence Number: 119092 Start / End Page: - Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166