English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Conserved exchange of paralog proteins during neuronal differentiation

Di Fraia, D., Anitei, M., Mackmull, M.-T., Parca, L., Behrendt, L., Andres-Pons, A., et al. (2022). Conserved exchange of paralog proteins during neuronal differentiation. Life science alliance, 5(6): e202201397. doi:10.26508/lsa.202201397.

Item is

Files

show Files
hide Files
:
e202201397.full.pdf (Any fulltext), 4MB
Name:
e202201397.full.pdf
Description:
-
OA-Status:
Not specified
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Di Fraia, Domenico1, Author
Anitei, Mihaela1, Author
Mackmull, Marie-Therese2, Author
Parca, Luca3, Author
Behrendt, Laura1, Author
Andres-Pons, Amparo4, Author
Gilmour, Darren5, Author
Helmer Citterich, Manuela3, Author
Kaether, Christoph1, Author
Beck, Martin6, Author                 
Ori, Alessandro1, Author
Affiliations:
1Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany, ou_persistent22              
2Eidgenössische Technische Hochschule (ETH) Zürich Inst. f. Molekulare Systembiologie, Zürich, Switzerland, ou_persistent22              
3Department of Biology, University of Tor Vergata, Rome, Italy, ou_persistent22              
4European Molecular Biology Laboratory, Heidelberg, Germany, ou_persistent22              
5Department of Molecular Life Sciences, University of Zurich, Zürich, Switzerland, ou_persistent22              
6Department of Molecular Sociology, Max Planck Institute of Biophysics, Max Planck Society, ou_3040395              

Content

show
hide
Free keywords: -
 Abstract: Gene duplication enables the emergence of new functions by lowering the evolutionary pressure that is posed on the ancestral genes. Previous studies have highlighted the role of specific paralog genes during cell differentiation, for example, in chromatin remodeling complexes. It remains unexplored whether similar mechanisms extend to other biological functions and whether the regulation of paralog genes is conserved across species. Here, we analyze the expression of paralogs across human tissues, during development and neuronal differentiation in fish, rodents and humans. Whereas ∼80% of paralog genes are co-regulated, a subset of paralogs shows divergent expression profiles, contributing to variability of protein complexes. We identify 78 substitutions of paralog pairs that occur during neuronal differentiation and are conserved across species. Among these, we highlight a substitution between the paralogs SEC23A and SEC23B members of the COPII complex. Altering the ratio between these two genes via RNAi-mediated knockdown is sufficient to influence neuron differentiation. We propose that remodeling of the vesicular transport system via paralog substitutions is an evolutionary conserved mechanism enabling neuronal differentiation.

Details

show
hide
Language(s): eng - English
 Dates: 2022-02-162022-02-012022-02-172022-03-10
 Publication Status: Published online
 Pages: 19
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.26508/lsa.202201397
BibTex Citekey: di_fraia_conserved_2022
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Life science alliance
  Abbreviation : Life Sci Alliance
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Heidelberg : EMBO Press
Pages: - Volume / Issue: 5 (6) Sequence Number: e202201397 Start / End Page: - Identifier: ISSN: 2575-1077
CoNE: https://pure.mpg.de/cone/journals/resource/2575-1077