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  Differential effects of anodal and dual tDCS on sensorimotor functions in chronic hemiparetic stroke patients

Muffel, T., Shih, P.-C., Kalloch, B., Nikulin, V. V., Villringer, A., & Sehm, B. (2022). Differential effects of anodal and dual tDCS on sensorimotor functions in chronic hemiparetic stroke patients. Brain Stimulation, 15(2), 509-522. doi:10.1016/j.brs.2022.02.013.

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Muffel, Toni1, 2, 3, 4, Author              
Shih, Pei-Cheng1, Author              
Kalloch, Benjamin1, 5, Author              
Nikulin, Vadim V.1, 6, 7, Author              
Villringer, Arno1, 2, 3, 4, Author              
Sehm, Bernhard1, 2, 8, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
3MindBrainBody Institute, Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
4Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              
5Faculty of Computer Science and Media, University of Applied Sciences, Leipzig, Germany, ou_persistent22              
6Neurophysics Group, Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
7Bernstein Center for Computational Neuroscience, Berlin, Germany, ou_persistent22              
8Department of Neurology, Martin Luther University Halle-Wittenberg, Germany, ou_persistent22              

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 Abstract: Background and purpose Previous tDCS studies in chronic stroke patients reported highly inconsistent effects on sensorimotor functions. Underlying reasons could be the selection of different kinematic parameters across studies and for different tDCS setups. We reasoned that tDCS may not simply induce global changes in a beneficial-adverse dichotomy, but rather that different sensorimotor kinematics are differentially affected. Furthermore, the often-postulated higher efficacy of bilateral-dual (bi-tDCS) over unilateral-anodal (ua-tDCS) could not yet be demonstrated consistently either. We investigated the effects of both setups on a wider range of kinematic parameters from standardized robotic tasks in patients with chronic stroke. Methods Twenty-four patients with arm hemiparesis received tDCS (20min, 1 mA) concurrent to kinematic assessments in a sham-controlled, cross-over and double-blind clinical trial. Performance was measured on four sensorimotor tasks (reaching, proprioception, cooperative and independent bimanual coordination) from which 30 parameters were extracted. On the group-level, the patterns of changes relative to sham were assessed using paired-samples t-tests and classified as (1) performance increases, (2) decreases and (3) non-significant differences. Correlations between parametric change scores were calculated for each task to assess effects on the individual-level. Results Both setups induced complex effect patterns with varying proportions of performance increases and decreases. On the group-level, more increases were induced in the reaching and coordination tasks while proprioception and bimanual cooperation were overall negatively affected. Bi-tDCS induced more performance increases and less decreases compared to ua-tDCS. Changes across parameters occurred more homogeneously under bi-tDCS than ua-tDCS, which induced a larger proportion of performance trade-offs. Conclusions Our data demonstrate profound tDCS effects on sensorimotor functions post-stroke, lending support for more pronounced and favorable effects of bi-tDCS compared to ua-tDCS. However, no uniformly beneficial pattern was identified. Instead, the modulations varied depending on the task and electrode setup, with increases in certain parameters occurring at the expense of decreases in others.

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Language(s): eng - English
 Dates: 2022-02-142021-02-092022-02-212022-03-042022-03
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.brs.2022.02.013
Other: epub 2022
PMID: 35248785
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Title: Brain Stimulation
  Abbreviation : Brain Stimul
Source Genre: Journal
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Publ. Info: New York, NY : Elsevier
Pages: - Volume / Issue: 15 (2) Sequence Number: - Start / End Page: 509 - 522 Identifier: ISSN: 1935-861X
CoNE: https://pure.mpg.de/cone/journals/resource/1935-861X