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  Cutting Edge: Serum but Not Mucosal Antibody Responses Are Associated with Pre-Existing SARS-CoV-2 Spike Cross-Reactive CD4+ T Cells following BNT162b2 Vaccination in the Elderly

Meyer-Arndt, L., Schwarz, T., Loyal, L., Henze, L., Kruse, B., Dingeldey, M., et al. (2022). Cutting Edge: Serum but Not Mucosal Antibody Responses Are Associated with Pre-Existing SARS-CoV-2 Spike Cross-Reactive CD4+ T Cells following BNT162b2 Vaccination in the Elderly. The Journal of Immunology, 2100990. doi:10.4049/jimmunol.2100990.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000A-22D0-4 Version Permalink: https://hdl.handle.net/21.11116/0000-000A-22D1-3
Genre: Journal Article

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J Immunol_Meyer-Arndt et al_2022.pdf (Publisher version), 2MB
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© 2022 by The American Association of Immunologists, Inc.
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 Creators:
Meyer-Arndt, Lil, Author
Schwarz, Tatjana, Author
Loyal, Lucie , Author
Henze, Larissa, Author
Kruse, Beate , Author
Dingeldey, Manuela , Author
Gürcan, Kübrah , Author
Uyar-Aydin, Zehra, Author
Müller, Marcel A. , Author
Drosten, Christian, Author
Paul, Friedemann , Author
Sander, Leif E. , Author
Demuth, Ilja , Author
Lauster, Roland, Author
Giesecke-Thiel, Claudia1, Author           
Braun, Julian , Author
Corman, Victor M., Author
Thiel, Andreas, Author
Affiliations:
1Flow Cytometry Facility (Head: Claudia Giesecke-Thiel), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_3039333              

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 Abstract: Advanced age is a main risk factor for severe COVID-19. However, low vaccination efficacy and accelerated waning immunity have been reported in this age group. To elucidate age-related differences in immunogenicity, we analyzed human cellular, serological, and salivary SARS-CoV-2 spike glycoprotein-specific immune responses to the BNT162b2 COVID-19 vaccine in old (69–92 y) and middle-aged (24–57 y) vaccinees compared with natural infection (COVID-19 convalescents, 21–55 y of age). Serological humoral responses to vaccination excee-ded those of convalescents, but salivary anti-spike subunit 1 (S1) IgA and neutralizing capacity were less durable in vaccinees. In old vaccinees, we observed that pre-existing spike-specific CD4+ T cells are associated with efficient induction of anti-S1 IgG and neutralizing capacity in serum but not saliva. Our results suggest pre-existing SARS-CoV-2 cross-reactive CD4+ T cells as a predictor of an efficient COVID-19 vaccine-induced humoral immune response in old individuals.

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Language(s): eng - English
 Dates: 2021-12-152022-02-04
 Publication Status: Published online
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 Identifiers: DOI: 10.4049/jimmunol.2100990
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Title: The Journal of Immunology
  Other : J. Immunol.
Source Genre: Journal
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Publ. Info: Baltimore, U.S.A. : Williams & Wilkins
Pages: - Volume / Issue: - Sequence Number: 2100990 Start / End Page: - Identifier: ISSN: 0022-1767 (Print) 1550-6606 (Online)
CoNE: https://pure.mpg.de/cone/journals/resource/954925414915_1