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  Signatures of life course socioeconomic conditions in brain anatomy

Loued-Khenissi, L., Trofimova, O., Vollenweider, P., Marques-Vidal, P., Preisig, M., Lutti, A., et al. (2022). Signatures of life course socioeconomic conditions in brain anatomy. Human Brain Mapping. doi:10.1002/hbm.25807.

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 Creators:
Loued-Khenissi, Leyla1, 2, Author
Trofimova, Olga1, Author
Vollenweider, Peter3, Author
Marques-Vidal, Pedro4, Author
Preisig, Martin4, Author
Lutti, Antoine1, Author
Kliegel, Matthias5, Author
Sandi, Carmen6, Author
Kherif, Ferhat1, Author
Stringhini, Silvia7, 8, Author
Draganski, Bogdan1, 9, Author              
Affiliations:
1Département des Neurosciences Cliniques, Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
2Theory of Pain Laboratory, University of Geneva, Switzerland, ou_persistent22              
3Department of Medicine, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
4Department of Psychiatry, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
5Laboratoire du Vieillissement Cognitif, University of Geneva, Switzerland, ou_persistent22              
6Laboratory of Behavioral Genetics, Swiss Federal Institute of Technology in Lausanne, Switzerland, ou_persistent22              
7Center for Primary Care and Public Health, University of Lausanne, Switzerland, ou_persistent22              
8Unit of Population Epidemiology, Division of Primary Care, University Hospital of Geneva, Switzerland, ou_persistent22              
9Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Multiparametric maps; Quantitative MRI; Socioeconomic status
 Abstract: Socioeconomic status (SES) plays a significant role in health and disease. At the same time, early-life conditions affect neural function and structure, suggesting the brain may be a conduit for the biological embedding of SES. Here, we investigate the brain anatomy signatures of SES in a large-scale population cohort aged 45-85 years. We assess both gray matter morphometry and tissue properties indicative of myelin content. Higher life course SES is associated with increased volume in several brain regions, including postcentral and temporal gyri, cuneus, and cerebellum. We observe more widespread volume differences and higher myelin content in the sensorimotor network but lower myelin content in the temporal lobe associated with childhood SES. Crucially, childhood SES differences persisted in adult brains even after controlling for adult SES, highlighting the unique contribution of early-life conditions to brain anatomy, independent of later changes in SES. These findings inform on the biological underpinnings of social inequality, particularly as they pertain to early-life conditions.

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Language(s): eng - English
 Dates: 2022-02-23
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/hbm.25807
Other: online ahead of print
PMID: 35195323
 Degree: -

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Project name : -
Grant ID : 633666
Funding program : -
Funding organization : European Commission
Project name : -
Grant ID : 320030 184784, 32003B 135679, 32003B 159780, 3200B0 105993, 3200B0 118308, 33CS30 139468, 33CS30 14840, 33CSCO 122661
Funding program : -
Funding organization : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686