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  Utility of the repeat and point test for subtyping patients with primary progressive aphasia

Seckin, M., Ricard, I., Raiser, T., Heitkamp, N., Ebert, A., Prix, C., et al. (2022). Utility of the repeat and point test for subtyping patients with primary progressive aphasia. Alzheimer Disease and Associated Disorders, 36(1), 44-51. doi:10.1097/WAD.0000000000000482.

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Genre: Journal Article

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 Creators:
Seckin, Mustafa, Author
Ricard, Ingrid, Author
Raiser, Theresa, Author
Heitkamp, Nari, Author
Ebert, Anne, Author
Prix, Catharina, Author
Levin, Johannes, Author
Diehl-Schmid, Janine, Author
Riedl, Lina, Author
Roßmeier, Carola, Author
Hoen, Nora, Author
Schroeter, Matthias L.1, Author              
Marschhauser, Anke1, Author              
Obrig, Hellmuth1, Author              
Benke, Thomas, Author
Kornhuber, Johannes, Author
Fliessbach, Klaus, Author
Schneider, Anja, Author
Wiltfang, Jens, Author
Jahn, Holger, Author
Fassbender, Klaus, AuthorPrudlo, Johannes, AuthorLauer, Martin, AuthorDuning, Thomas, AuthorWilke, Carlo, AuthorSynofzik, Matthis, AuthorAnderl-Straub, Sarah, AuthorSemler, Elisa, AuthorLombardi, Jolina, AuthorLandwehrmeyer, Bernard, AuthorLudolph, Albert, AuthorOtto, Markus, AuthorGerman FTLD consortium, Author              Danek, Adrian, Author more..
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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 Abstract: Background: Primary progressive aphasia (PPA) may present with three distinct clinical sybtypes: semantic variant PPA (svPPA), nonfluent/agrammatic variant PPA (nfvPPA), and logopenic variant PPA (lvPPA). Objective: The aim was to examine the utility of the German version of the Repeat and Point (R&P) Test for subtyping patients with PPA. Method: During the R&P Test, the examiner reads out aloud a noun and the participants are asked to repeat the word and subsequently point to the corresponding picture. Data from 204 patients (68 svPPA, 85 nfvPPA, and 51 lvPPA) and 33 healthy controls were analyzed. Results: Controls completed both tasks with >90% accuracy. Patients with svPPA had high scores in repetition (mean=9.2±1.32) but low scores in pointing (mean=6±2.52). In contrast, patients with nfvPPA and lvPPA performed comparably in both tasks with lower scores in repetition (mean=7.4±2.7 for nfvPPA and 8.2±2.34 for lvPPA) but higher scores in pointing (mean=8.9±1.41 for nfvPPA and 8.6±1.62 for lvPPA). The R&P Test had high accuracy discriminating svPPA from nfvPPA (83% accuracy) and lvPPA (79% accuracy). However, there was low accuracy discriminating nfvPPA from lvPPA (<60%). Conclusion: The R&P Test helps to differentiate svPPA from 2 nonsemantic variants (nfvPPA and lvPPA). However, additional tests are required for the differentiation of nfvPPA and lvPPA.

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Language(s): eng - English
 Dates: 2022-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1097/WAD.0000000000000482
PMID: 35001030
 Degree: -

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Title: Alzheimer Disease and Associated Disorders
Source Genre: Journal
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Affiliations:
Publ. Info: Lawrence, Kan. : Western Geriatric Research Institute
Pages: - Volume / Issue: 36 (1) Sequence Number: - Start / End Page: 44 - 51 Identifier: ISSN: 0893-0341
CoNE: https://pure.mpg.de/cone/journals/resource/954925558484