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  Increase in b-wave amplitude after light stimulation of the blind spot is positively correlated with the axial length of myopic individuals

Schilling, T., Amorim-de-Sousa, A., Wong, N., Bahmani, H., González-Méijome, J., & Fernandes, P. (2022). Increase in b-wave amplitude after light stimulation of the blind spot is positively correlated with the axial length of myopic individuals. Scientific Reports, 12(1): 4785. doi:10.1038/s41598-022-08319-5.

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Schilling, T, Author
Amorim-de-Sousa, A, Author
Wong, NA, Author
Bahmani, H1, 2, Author              
González-Méijome, JN, Author
Fernandes, P, Author
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Altered retinal dopamine and ON-pathway activity may underlie myopia development. It has been shown that the stimulation of the blind spot with short-wavelength light increases the electroretinogram (ERG) b-wave amplitude of myopic eyes and may engage the retinal dopaminergic system. This study evaluated the impact of various durations of blind spot stimulation on the electrophysiological response of the myopic retina and their relationship to axial length. Six myopic individuals underwent three short-wavelength blue light blind spot stimulation protocols (10 s, 1 min, 10 min) using a virtual reality headset. As a control condition, no stimulation was shown for 1 min. The b-wave amplitude of the photopic full-field ERG was measured at baseline and 10, 20, 30, 40, 50, and 60 min after each condition. A significant increase in b-wave amplitude was observed for all stimulation protocols compared to the control. The peak b-wave amplitude was observed 20 min after the 1-min stimulation protocol and 60 min after the 10-min stimulation protocol. A significant positive correlation was found between axial length of the eye and percent change in b-wave amplitude for the 10-min stimulation protocol. A rapid and a delayed b-wave time course responses were observed following 1 min and 10 min of blind spot stimulation, respectively. Overall, these results indicate that light stimulation of the blind spot for various durations elevates ON-bipolar cell activity in the retina and as such is assumed to reduce the myopic response. These findings could have implications for future myopia treatment.

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 Dates: 2022-03
 Publication Status: Published online
 Pages: 12
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s41598-022-08319-5
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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 12 (1) Sequence Number: 4785 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322