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  Stability over time of scores on psychiatric rating scales, questionnaires and cognitive tests in healthy controls

Stahl, K., Adorjan, K., Anderson-Schmidt, H., Budde, M., Comes, A. L., Gade, K., et al. (2022). Stability over time of scores on psychiatric rating scales, questionnaires and cognitive tests in healthy controls. BJPSYCH OPEN, 8(2): e55. doi:10.1192/bjo.2022.17.

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 Creators:
Stahl, Katharina, Author
Adorjan, Kristina, Author
Anderson-Schmidt, Heike, Author
Budde, Monika, Author
Comes, Ashley L., Author
Gade, Katrin, Author
Heilbronner, Maria, Author
Kalman, Janos L.1, Author           
Kloehn-Saghatolislam, Farahnaz, Author
Kohshour, Mojtaba Oraki, Author
Papiol, Sergi, Author
Reich-Erkelenz, Daniela, Author
Schaupp, Sabrina K., Author
Schulte, Eva C., Author
Senner, Fanny, Author
Vogl, Thomas, Author
Wiltfang, Jens, Author
Reininghaus, Eva, Author
Falkai, Peter, Author
Schulze, Thomas G., Author
Bickeboeller, Heike, AuthorHeilbronner, Urs, Author more..
Affiliations:
1IMPRS Translational Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_3318616              

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 Abstract: Background Case-only longitudinal studies are common in psychiatry. Further, it is assumed that psychiatric ratings and questionnaire results of healthy controls stay stable over foreseeable time ranges. For cognitive tests, improvements over time are expected, but data for more than two administrations are scarce. Aims We comprehensively investigated the longitudinal course for trends over time in cognitive and symptom measurements for severe mental disorders. Assessments included the Trail Making Tests, verbal Digit Span tests, Global Assessment of Functioning, Inventory of Depressive Symptomatology, the Positive and Negative Syndrome Scale, and the Young Mania Rating Scale, among others. Method Using the data of control individuals (n = 326) from the PsyCourse study who had up to four assessments over 18 months, we modelled the course using linear mixed models or logistic regression. The slopes or odds ratios were estimated and adjusted for age and gender. We also assessed the robustness of these results using a longitudinal non-parametric test in a sensitivity analysis. Results Small effects were detected for most cognitive tests, indicating a performance improvement over time (P < 0.05). However, for most of the symptom rating scales and questionnaires, no effects were detected, in line with our initial hypothesis. Conclusions The slightly but consistently improved performance in the cognitive tests speaks of a test-unspecific positive trend, while psychiatric ratings and questionnaire results remain stable over the observed period. These detectable improvements need to be considered when interpreting longitudinal courses. We therefore recommend recruiting control participants if cognitive tests are administered.

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 Dates: 2022-03-02
 Publication Status: Published online
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 Rev. Type: -
 Identifiers: ISI: 000762773300001
DOI: 10.1192/bjo.2022.17
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Title: BJPSYCH OPEN
Source Genre: Journal
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Pages: - Volume / Issue: 8 (2) Sequence Number: e55 Start / End Page: - Identifier: ISSN: 2056-4724