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  CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves

Eichel, M. A., Gargareta, V.-I., D’Este, E., Fledrich, R., Kungl, T., Buscham, T. J., et al. (2020). CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves. Nature Communications, 11(1): 4514. doi:10.1038/s41467-020-18172-7.

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Eichel, M. A.1, Author           
Gargareta, V.-I.1, Author           
D’Este, E., Author
Fledrich, R.2, Author           
Kungl, T.1, Author           
Buscham, T. J.1, Author           
Lüders, K. A.1, Author           
Miracle, C.1, Author           
Jung, R. B.1, Author           
Distler, Ute, Author
Kusch, K.1, Author           
Möbius, W.3, Author           
Hülsmann, S., Author
Tenzer, S., Author
Nave, K.-A.1, Author           
Werner, H. B.1, Author
Affiliations:
1Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173664              
2Molecular and translational neurology, Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173667              
3Electron microscopy, Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173666              

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 Abstract: The velocity of nerve conduction is moderately enhanced by larger axonal diameters and potently sped up by myelination of axons. Myelination thus allows rapid impulse propagation with reduced axonal diameters; however, no myelin-dependent mechanism has been reported that restricts radial growth of axons. By label-free proteomics, STED-microscopy and cryo-immuno electron-microscopy we here identify CMTM6 (chemokine-like factor-like MARVEL-transmembrane domain-containing family member-6) as a myelin protein specifi- cally localized to the Schwann cell membrane exposed to the axon. We find that disruption of Cmtm6-expression in Schwann cells causes a substantial increase of axonal diameters but does not impair myelin biogenesis, radial sorting or integrity of axons. Increased axonal diameters correlate with accelerated sensory nerve conduction and sensory responses and perturbed motor performance. These data show that Schwann cells utilize CMTM6 to restrict the radial growth of axons, which optimizes nerve function.

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Language(s): eng - English
 Dates: 2020-09-09
 Publication Status: Published online
 Pages: 12
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41467-020-18172-7
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Title: Nature Communications
Source Genre: Journal
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Pages: 12 Volume / Issue: 11 (1) Sequence Number: 4514 Start / End Page: - Identifier: ISSN: 2041-1723