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  A role of oligodendrocytes in information processing

Moore, S., Meschkat, M., Ruhwedel, T., Trevisiol, A., Tzvetanova, I., Battefeld, A., et al. (2020). A role of oligodendrocytes in information processing. Nature Communications, 11(1): 5497. doi:10.1038/s41467-020-19152-7.

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 Creators:
Moore, S.1, Author           
Meschkat, M.1, Author           
Ruhwedel, T.2, Author           
Trevisiol, A.1, Author           
Tzvetanova, I.1, Author           
Battefeld, A., Author
Kusch, K.1, Author           
Kole, M. H. P., Author
Strenzke, N., Author
Möbius, W.2, Author           
de Hoz, L.3, Author           
Nave, K.-A.1, Author           
Affiliations:
1Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173664              
2Electron microscopy, Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173666              
3Cognitive Neurophysiology Lab, Department of Neurogenetics, Max Planck Institute for Experimental Medicine, Göttingen, Germany, ou_persistent22              

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 Abstract: Myelinating oligodendrocytes enable fast propagation of action potentials along the ensheathed axons. In addition, oligodendrocytes play diverse non-canonical roles including axonal metabolic support and activity-dependent myelination. An open question remains whether myelination also contributes to information processing in addition to speeding up conduction velocity. Here, we analyze the role of myelin in auditory information processing using paradigms that are also good predictors of speech understanding in humans. We compare mice with different degrees of dysmyelination using acute multiunit recordings in the auditory cortex, in combination with behavioral readouts. We find complex alterations of neuronal responses that reflect fatigue and temporal acuity deficits. We observe partially discriminable but similar deficits in well myelinated mice in which glial cells cannot fully support axons metabolically. We suggest a model in which myelination contributes to sus- tained stimulus perception in temporally complex paradigms, with a role of metabolically active oligodendrocytes in cortical information processing.

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Language(s): eng - English
 Dates: 2020-10-30
 Publication Status: Published online
 Pages: 15
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41467-020-19152-7
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Title: Nature Communications
Source Genre: Journal
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Pages: 15 Volume / Issue: 11 (1) Sequence Number: 5497 Start / End Page: - Identifier: ISSN: 2041-1723