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  The human α-defensin-derived peptide HD5(1-9) inhibits cellular attachment and entry of human cytomegalovirus

Böffert, R., Businger, R., Preiß, H., Ehmann, D., Truffault, V., Simon, C., et al. (2020). The human α-defensin-derived peptide HD5(1-9) inhibits cellular attachment and entry of human cytomegalovirus. Antiviral Research, 177: 104779. doi:10.1016/j.antiviral.2020.104779.

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Böffert, R, Author
Businger, R, Author
Preiß, H1, Author           
Ehmann, D, Author
Truffault, V, Author           
Simon, C, Author
Ruetalo, N, Author
Hamprecht, K, Author
Müller, P1, Author           
Wehkamp, J, Author
Schindler, M, Author
Affiliations:
1Müller Group, Friedrich Miescher Laboratory, Max Planck Society, ou_3008690              

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 Abstract: Human cytomegalovirus (HCMV) infection causes severe illness in newborns and immunocompromised patients. Since treatment options are limited there is an unmet need for new therapeutic approaches. Defensins are cationic peptides, produced by various human tissues, which serve as antimicrobial effectors of the immune system. Furthermore, some defensins are proteolytically cleaved, resulting in the generation of smaller fragments with increased activity. Together, this led us to hypothesize that defensin-derived peptides are natural human inhibitors of virus infection with low toxicity. We screened several human defensin HNP4- and HD5-derived peptides and found HD5(1-9) to be antiviral without toxicity at high concentrations. HD5(1-9) inhibited HCMV cellular attachment and thereby entry and was active against primary as well as a multiresistant HCMV isolate. Moreover, cysteine and arginine residues were identified to mediate the antiviral activity of HD5(1-9). Altogether, defensin-derived peptides, in particular HD5(1-9), qualify as promising candidates for further development as a novel class of HCMV entry inhibitors.

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 Dates: 2020-05
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.antiviral.2020.104779
PMID: 32209394
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Title: Antiviral Research
  Other : Antiviral Res.
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 177 Sequence Number: 104779 Start / End Page: - Identifier: ISSN: 0166-3542
CoNE: https://pure.mpg.de/cone/journals/resource/954925482631