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  Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease

Oliveira, L. M. A., Gasser, T., Edwards, R., Zweckstetter, M., Melki, R., Stefanis, L., et al. (2021). Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease. NPJ Parkinsons Disease, 7: 65. doi:10.1038/s41531-021-00203-9.

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 Creators:
Oliveira, L. M. A., Author
Gasser, T., Author
Edwards, R., Author
Zweckstetter, M.1, Author              
Melki, R., Author
Stefanis, L., Author
Lashuel, H. A., Author
Sulzer, D., Author
Vekrellis, K., Author
Halliday, G. M., Author
Tomlinson, J. J., Author
Schlossmacher, M., Author
Jensen, P. H., Author
Schulze-Hentrich, J., Author
Riess, O., Author
Hirst, W.D., Author
El-Agnaf, O., Author
Mollenhauer, B., Author
Lansbury, P., Author
Outeiro, T. F., Author
Affiliations:
1Research Group of Protein Structure Determination using NMR, MPI for biophysical chemistry, Max Planck Society, ou_578571              

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Free keywords: Parkinson's disease
 Abstract: With the advent of the genetic era in Parkinson’s disease (PD) research in 1997, α-synuclein was identified as an important player in a complex neurodegenerative disease that affects >10 million people worldwide. PD has been estimated to have an economic impact of $51.9 billion in the US alone. Since the initial association with PD, hundreds of researchers have contributed to elucidating the functions of α-synuclein in normal and pathological states, and these remain critical areas for continued research. With this position paper the authors strive to achieve two goals: first, to succinctly summarize the critical features that define α-synuclein’s varied roles, as they are known today; and second, to identify the most pressing knowledge gaps and delineate a multipronged strategy for future research with the goal of enabling therapies to stop or slow disease progression in PD.

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Language(s): eng - English
 Dates: 2021-07-26
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41531-021-00203-9
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Title: NPJ Parkinsons Disease
Source Genre: Journal
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Pages: 23 Volume / Issue: 7 Sequence Number: 65 Start / End Page: - Identifier: -