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  Fine-scale genetic structure in the United Arab Emirates reflects endogamous and consanguineous culture, population history, and geography

Elliott, K. S., Haber, M., Daggag, H., Busby, G. B., Sarwar, R., Kennet, D., et al. (2022). Fine-scale genetic structure in the United Arab Emirates reflects endogamous and consanguineous culture, population history, and geography. Molecular Biology and Evolution, 39(3): msac039, pp. 1-11. doi:10.1093/molbev/msac039.

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 Creators:
Elliott, Katherine S, Author
Haber, Marc, Author
Daggag, Hinda, Author
Busby, George B, Author
Sarwar, Rizwan, Author
Kennet, Derek, Author
Petraglia, Michael1, Author           
Petherbridge, Lawrence J, Author
Yavari, Parisa, Author
Heard-Bey, Frauke U, Author
Shobi, Bindu, Author
Ghulam, Tariq, Author
Haj, Dalia, Author
Al Tikriti, Alia, Author
Mohammad, Alshafi, Author
Antony, Suma, Author
Alyileili, Maitha, Author
Alaydaroos, Shatha, Author
Lau, Evelyn, Author
Butler, Mark, Author
Yavari, Arash, AuthorKnight, Julian C, AuthorAshrafian, Houman, AuthorBarakat, Maha T, Author more..
Affiliations:
1Archaeology, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074312              

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Free keywords: population genetics, ancestry, admixture, Middle East
 Abstract: The indigenous population of the United Arab Emirates (UAE) has a unique demographic and cultural history. Its tradition of endogamy and consanguinity is expected to produce genetic homogeneity and partitioning of gene pools while population movements and intercontinental trade are likely to have contributed to genetic diversity. Emiratis and neighboring populations of the Middle East have been underrepresented in the population genetics literature with few studies covering the broader genetic history of the Arabian Peninsula. Here, we genotyped 1,198 individuals from the seven Emirates using 1.7 million markers and by employing haplotype-based algorithms and admixture analyses, we reveal the fine-scale genetic structure of the Emirati population. Shared ancestry and gene flow with neighboring populations display their unique geographic position while increased intra- versus inter-Emirati kinship and sharing of uniparental haplogroups, reflect the endogamous and consanguineous cultural traditions of the Emirates and their tribes.

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Language(s): eng - English
 Dates: 2022-02-222022-03
 Publication Status: Published in print
 Pages: 11
 Publishing info: -
 Table of Contents: Introduction
Results
- Data Set, Genotyping, and Homozygosity
- Population Structure and Admixture
- Y Chromosome and Mitochondrial Haplogroup Analysis
Discussion
Materials and Methods
- Sample Collection and Selection
- Genotyping and QC
- Homozygosity
- Principal Components Analysis: Projection onto 1000G Weightings
- Phasing
- Painting Chromosomes with CHROMOPAINTER
- Using Painted Chromosomes to Infer Shared Ancestry
- Using Painted Chromosomes with fineSTRUCTURE
- Admixture Tests
- Inference of Population Maximum-Likelihood Tree and Migration Events
- Estimating Admixture Dates
- Y Haplogroup Assignment for Patrilineal Inheritance
- Mitochondrial Haplogroup Assignment for Matrilineal Inheritance
- Y Chromosome and Mitochondrial Variants Present in Our Data Set
- Statistical Analysis
- Publicly Available Data Sets and Resources
- Tools and Software
- Managed Data Access
 Rev. Type: Peer
 Identifiers: DOI: 10.1093/molbev/msac039
Other: shh3179
 Degree: -

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Title: Molecular Biology and Evolution
  Other : Mol. Biol. Evol.
Source Genre: Journal
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Publ. Info: Oxford : Oxford University Press
Pages: - Volume / Issue: 39 (3) Sequence Number: msac039 Start / End Page: 1 - 11 Identifier: ISSN: 0737-4038
CoNE: https://pure.mpg.de/cone/journals/resource/954925536119