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  Fine-scale genetic structure in the United Arab Emirates reflects endogamous and consanguineous culture, population history, and geography

Elliott, K. S., Haber, M., Daggag, H., Busby, G. B., Sarwar, R., Kennet, D., et al. (2022). Fine-scale genetic structure in the United Arab Emirates reflects endogamous and consanguineous culture, population history, and geography. Molecular Biology and Evolution, 39(3): msac039, pp. 1-11. doi:10.1093/molbev/msac039.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-000A-322C-D Versions-Permalink: https://hdl.handle.net/21.11116/0000-0010-2B2E-C
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externe Referenz:
Supplemental Fig. 1-6; Supplementary tables 1-6; Genotypes (Ergänzendes Material)
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 Urheber:
Elliott, Katherine S, Autor
Haber, Marc, Autor
Daggag, Hinda, Autor
Busby, George B, Autor
Sarwar, Rizwan, Autor
Kennet, Derek, Autor
Petraglia, Michael1, Autor           
Petherbridge, Lawrence J, Autor
Yavari, Parisa, Autor
Heard-Bey, Frauke U, Autor
Shobi, Bindu, Autor
Ghulam, Tariq, Autor
Haj, Dalia, Autor
Al Tikriti, Alia, Autor
Mohammad, Alshafi, Autor
Antony, Suma, Autor
Alyileili, Maitha, Autor
Alaydaroos, Shatha, Autor
Lau, Evelyn, Autor
Butler, Mark, Autor
mehr..
Affiliations:
1Archaeology, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074312              

Inhalt

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Schlagwörter: population genetics, ancestry, admixture, Middle East
 Zusammenfassung: The indigenous population of the United Arab Emirates (UAE) has a unique demographic and cultural history. Its tradition of endogamy and consanguinity is expected to produce genetic homogeneity and partitioning of gene pools while population movements and intercontinental trade are likely to have contributed to genetic diversity. Emiratis and neighboring populations of the Middle East have been underrepresented in the population genetics literature with few studies covering the broader genetic history of the Arabian Peninsula. Here, we genotyped 1,198 individuals from the seven Emirates using 1.7 million markers and by employing haplotype-based algorithms and admixture analyses, we reveal the fine-scale genetic structure of the Emirati population. Shared ancestry and gene flow with neighboring populations display their unique geographic position while increased intra- versus inter-Emirati kinship and sharing of uniparental haplogroups, reflect the endogamous and consanguineous cultural traditions of the Emirates and their tribes.

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Sprache(n): eng - English
 Datum: 2022-02-222022-03
 Publikationsstatus: Erschienen
 Seiten: 11
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: Introduction
Results
- Data Set, Genotyping, and Homozygosity
- Population Structure and Admixture
- Y Chromosome and Mitochondrial Haplogroup Analysis
Discussion
Materials and Methods
- Sample Collection and Selection
- Genotyping and QC
- Homozygosity
- Principal Components Analysis: Projection onto 1000G Weightings
- Phasing
- Painting Chromosomes with CHROMOPAINTER
- Using Painted Chromosomes to Infer Shared Ancestry
- Using Painted Chromosomes with fineSTRUCTURE
- Admixture Tests
- Inference of Population Maximum-Likelihood Tree and Migration Events
- Estimating Admixture Dates
- Y Haplogroup Assignment for Patrilineal Inheritance
- Mitochondrial Haplogroup Assignment for Matrilineal Inheritance
- Y Chromosome and Mitochondrial Variants Present in Our Data Set
- Statistical Analysis
- Publicly Available Data Sets and Resources
- Tools and Software
- Managed Data Access
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1093/molbev/msac039
Anderer: shh3179
 Art des Abschluß: -

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Quelle 1

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Titel: Molecular Biology and Evolution
  Andere : Mol. Biol. Evol.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Oxford : Oxford University Press
Seiten: - Band / Heft: 39 (3) Artikelnummer: msac039 Start- / Endseite: 1 - 11 Identifikator: ISSN: 0737-4038
CoNE: https://pure.mpg.de/cone/journals/resource/954925536119