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  Combining elemental and immunochemical analyses to characterize diagenetic alteration patterns in ancient skeletal remains

Gatti, L., Lugli, F., Sciutto, G., Zangheri, M., Prati, S., Mirasoli, M., et al. (2022). Combining elemental and immunochemical analyses to characterize diagenetic alteration patterns in ancient skeletal remains. Scientific Reports, 12(1): 5112. doi:10.1038/s41598-022-08979-3.

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 Creators:
Gatti, L., Author
Lugli, Federico, Author
Sciutto, Giorgia, Author
Zangheri, M., Author
Prati, S., Author
Mirasoli, M., Author
Silvestrini, S., Author
Benazzi, S., Author
Tütken, T., Author
Douka, Katerina1, Author              
Collina, C., Author
Boschin, F., Author
Romandini, M., Author
Iacumin, P., Author
Guardigli, M., Author
Roda, A., Author
Mazzeo, R., Author
Affiliations:
1Archaeology, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074312              

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Free keywords: Archaeology, Bioanalytical chemistry, Biogeochemistry, Chemistry, Imaging studies, Mass spectrometry, Palaeontology
 Abstract: Bones and teeth are biological archives, but their structure and composition are subjected to alteration overtime due to biological and chemical degradation postmortem, influenced by burial environment and conditions. Nevertheless, organic fraction preservation is mandatory for several archeometric analyses and applications. The mutual protection between biomineral and organic fractions in bones and teeth may lead to a limited diagenetic alteration, promoting a better conservation of the organic fraction. However, the correlation between elemental variations and the presence of organic materials (e.g., collagen) in the same specimen is still unclear. To fill this gap, chemiluminescent (CL) immunochemical imaging analysis has been applied for the first time for collagen localization. Then, Laser Ablation–Inductively Coupled Plasma–Mass Spectrometry (LA–ICP–MS) and CL imaging were combined to investigate the correlation between elemental (i.e., REE, U, Sr, Ba) and collagen distribution. Teeth and bones from various archeological contexts, chronological periods, and characterized by different collagen content were analyzed. Immunochemical analysis revealed a heterogeneous distribution of collagen, especially in highly degraded samples. Subsequently, LA–ICP–MS showed a correlation between the presence of uranium and rare earth elements and areas with low amount of collagen. The innovative integration between the two methods permitted to clarify the mutual relation between elemental variation and collagen preservation overtime, thus contributing to unravel the effects of diagenetic alteration in bones and teeth.

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Language(s): eng - English
 Dates: 2022-03-24
 Publication Status: Published online
 Pages: 14
 Publishing info: -
 Table of Contents: Results
- Bone samples.
- Tooth sample.
Discussion
Materials and methods
- Sample preparation.
- Laser ablation ICP–MS analyses.
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41598-022-08979-3
Other: shh3180
 Degree: -

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 12 (1) Sequence Number: 5112 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322