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  Immune competence and spleen size scale with colony status in the naked mole-rat

Bégay, V., Cirovic, B., Barker, A. J., Klopfleisch, R., Hart, D. W., Bennett, N. C., et al. (2022). Immune competence and spleen size scale with colony status in the naked mole-rat. Open Biol, 12(4): 210292. doi:10.1098/rsob.210292.

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Published by the Royal Society under the terms of the Creative Commons AttributionLicense http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the originalauthor and source are credited.

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Bégay, Valérie1, Author
Cirovic, Branko2, Author
Barker, Alison J.1, 3, Author           
Klopfleisch, Robert4, Author
Hart, Daniel W5, Author
Bennett, Nigel C5, Author
Lewin, Gary R1, Author
Affiliations:
1Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Laboratory for Molecular Physiology of Somatic Sensation, Robert-Rössle Straße 10, D-13125 Berlin, Germany., ou_persistent22              
2Division of Cellular Immunology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany., ou_persistent22              
3Social Systems and Circuits Group, Max Planck Institute for Brain Research, Max Planck Society, ou_3334049              
4Institute of Veterinary Pathology, Free University Berlin, Robert von Ostertag Strasse 15, 14163 Berlin, Germany., ou_persistent22              
5Mammal Research Institute, Department of Zoology and Entomology, University of Pretoria, Pretoria, Republic of South Africa., ou_persistent22              

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Free keywords: hyperplasic spleen/splenomegaly, adaptive immune system, lymphopoiesis, extramedullary haematopoiesis, eusociality, naked mole-rat
 Abstract: Naked mole-rats (NM-R; Heterocephalus glaber) live in multi-generational colonies with a social hierarchy, and show low cancer incidence and long life-spans. Here we asked if an immune component might underlie such extreme physiology. The largest lymphoid organ is the spleen, which plays an essential role in responding to immunological insults and may participate in combating cancer and slowing ageing. We investigated the anatomy, molecular composition and function of the NM-R spleen using RNA-sequencing and histological analysis in healthy NM-Rs. Spleen size in healthy NM-Rs showed considerable inter-individual variability, with some animals displaying enlarged spleens. In all healthy NM-Rs, the spleen is a major site of adult haematopoiesis under normal physiological conditions. However, myeloid-to-lymphoid cell ratio is increased and splenic marginal zone showed markedly altered morphology when compared to other rodents. Healthy NM-Rs with enlarged spleens showed potentially better anti-microbial profiles and were much more likely to have a high rank within the colony. We propose that the anatomical plasticity of the spleen might be regulated by social interaction and gives immunological advantage to increase the lifespan of higher-ranked animals.

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Language(s): eng - English
 Dates: 2021-09-292022-02-182022-04-06
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1098/rsob.210292
PMID: 35382566
 Degree: -

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Title: Open Biol
Source Genre: Journal
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Publ. Info: London : The Royal Society
Pages: - Volume / Issue: 12 (4) Sequence Number: 210292 Start / End Page: - Identifier: ISSN: 2046-2441
CoNE: https://pure.mpg.de/cone/journals/resource/2046-2441