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  Target highlights in CASP14: Analysis of models by structure providers

Alexander, L., Lepore, R., Kryshtafovych, A., Adamopoulos, A., Alahuhta, M., Arvin, A., et al. (2021). Target highlights in CASP14: Analysis of models by structure providers. Proteins: Structure, Function, and Genetics, 89(12), 1647-1672. doi:10.1002/prot.26247.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-000A-3A93-F Versions-Permalink: https://hdl.handle.net/21.11116/0000-000B-B38F-A
Genre: Zeitschriftenartikel

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 Urheber:
Alexander, LT, Autor
Lepore, R, Autor
Kryshtafovych, A, Autor
Adamopoulos, A, Autor
Alahuhta, M, Autor
Arvin, AM, Autor
Bomble, YJ, Autor
Böttcher, B, Autor
Breyton, C, Autor
Chiarini, AV, Autor
Chinnam, NB, Autor
Chiu, W, Autor
Fidelis, K, Autor
Grinter, R, Autor
Gupta, GD, Autor
Hartmann, MD1, 2, Autor           
Hayes, CS, Autor
Heidebrecht, T, Autor
Ilari, A, Autor
Joachimiak, A, Autor
Kim, Y, AutorLinares, R, AutorLovering, AL, AutorLunin, VL, AutorLupas, AN1, Autor           Makbul, C, AutorMichalska, K, AutorMoult, J, AutorMukherjee, PK, AutorNutt, WS, AutorOliver, SL, AutorPerrakis, A, AutorStols, L, AutorTainer, JA, AutorTopf, M, AutorTsutakawa, SE, AutorValdivia-Delgado, M, AutorSchwede, T, Autor mehr..
Affiliations:
1Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3375791              
2Molecular Recognition and Catalysis Group, Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3477392              

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 Zusammenfassung: The biological and functional significance of selected Critical Assessment of Techniques for Protein Structure Prediction 14 (CASP14) targets are described by the authors of the structures. The authors highlight the most relevant features of the target proteins and discuss how well these features were reproduced in the respective submitted predictions. The overall ability to predict three-dimensional structures of proteins has improved remarkably in CASP14, and many difficult targets were modeled with impressive accuracy. For the first time in the history of CASP, the experimentalists not only highlighted that computational models can accurately reproduce the most critical structural features observed in their targets, but also envisaged that models could serve as a guidance for further studies of biologically-relevant properties of proteins.

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 Datum: 2021-12
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1002/prot.26247
PMID: 34561912
 Art des Abschluß: -

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Titel: Proteins: Structure, Function, and Genetics
  Andere : Proteins: Struct., Funct., Genet.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York, NY : John Wiley & Sons
Seiten: - Band / Heft: 89 (12) Artikelnummer: - Start- / Endseite: 1647 - 1672 Identifikator: ISSN: 0887-3585
CoNE: https://pure.mpg.de/cone/journals/resource/954925553393