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  Multicenter 18F-PI-2620 PET for in vivo Braak staging of tau pathology in Alzheimer’s disease

Rullmann, M., Brendel, M., Schroeter, M. L., Saur, D., Levin, J., Perneczky, R. G., et al. (2022). Multicenter 18F-PI-2620 PET for in vivo Braak staging of tau pathology in Alzheimer’s disease. Biomolecules, 12(3): 458. doi:10.3390/biom12030458.

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 Creators:
Rullmann, Michael1, Author
Brendel, Matthias2, Author
Schroeter, Matthias L.3, 4, Author              
Saur, Dorothee5, Author
Levin, Johannes6, 7, 8, Author
Perneczky, Robert G.7, 8, 9, 10, 11, Author
Tiepolt, Solveig1, Author
Patt, Marianne1, Author
Mueller, Andre12, Author
Villemagne, Victor L.13, Author
Classen, Joseph5, Author
Stephens, Andrew W.12, Author
Sabri, Osama1, Author
Barthel, Henryk1, Author
Affiliations:
1Department of Nuclear Medicine, University of Leipzig, Germany, ou_persistent22              
2Department of Nuclear Medicine, Ludwig Maximilians University Munich, Germany, ou_persistent22              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
5Department of Neurology, University Hospital Leipzig, Germany, ou_persistent22              
6Department of Neurology, Ludwig Maximilians University Munich, Germany, ou_persistent22              
7Munich Cluster for Systems Neurology (SyNergy), Ludwig Maximilians University Munich, Germany, ou_persistent22              
8German Center for Neurodegenerative Diseases (DZNE), Munich, Germany, ou_persistent22              
9Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Germany, ou_persistent22              
10Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, United Kingdom, ou_persistent22              
11Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, United Kingdom, ou_persistent22              
12Life Molecular Imaging GmbH, Berlin, Germany, ou_persistent22              
13Department of Psychiatry, University of Pittsburgh, PA, USA, ou_persistent22              

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Free keywords: Alzheimer’s disease; Braak staging; PET; PI-2620; Tau
 Abstract: Tau aggregates accumulate in the Alzheimer's disease (AD) brain according to the established Braak staging scheme and spread from transentorhinal over limbic regions to the neocortex. To impact the management of AD patients, an in vivo tool for tau Braak staging is needed. First-generation tau tracers have limited performance in detecting early stages of tau. Therefore, we tested the corresponding capability of the next-generation tau tracer, 18F-PI-2620. We analyzed 18F-PI-2620 multicenter PET data from 37 beta-amyloid-positive AD dementia patients and those from 26 healthy controls. We applied kinetic modeling of the 0-60 min p.i. PET data using MRTM2 with the lower cerebellum as the reference region to extract Braak stage-dependent distribution volume ratios, whereas controls were used to define Braak stage PET positivity thresholds. Stage-dependent PET positivity widely followed the Braak scheme (except Braak stage III) presenting descending frequency of PET positivity from Braak I (43%), II (38%), III (49%), IV (35%), V (30%) to VI (14%). A strictly hierarchical model was met by 64% of AD dementia cases. Nineteen percent showed a hippocampal sparing tauopathy pattern. Thus, we could assign 87% to the six-stage hierarchical Braak model including tauopathy variants. 18F-PI-2620 PET appears to be able to perform Braak tau staging of AD in vivo.

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Language(s): eng - English
 Dates: 2022-03-092022-01-252022-03-122022-03-16
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3390/biom12030458
PMID: 35327650
PMC: PMC8946049
 Degree: -

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Title: Biomolecules
Source Genre: Journal
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Publ. Info: Basel, Switzerland : MDPI
Pages: - Volume / Issue: 12 (3) Sequence Number: 458 Start / End Page: - Identifier: ISSN: 2218-273X
CoNE: https://pure.mpg.de/cone/journals/resource/2218-273X