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  The effect of external stimulation on functional networks in the aging healthy human brain

Escrichs, A., Sanz Perl, Y., Martínez-Molina, N., Biarnes, C., Garre-Olmo, J., Fernández-Real, J. M., et al. (2022). The effect of external stimulation on functional networks in the aging healthy human brain. Cerebral Cortex. doi:10.1093/cercor/bhac064.

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 Creators:
Escrichs, Anira1, Author
Sanz Perl, Yonatan1, Author
Martínez-Molina, Noelia1, Author
Biarnes, Carles1, Author
Garre-Olmo, Josep1, Author
Fernández-Real, José Manuel1, Author
Ramos, Rafel1, Author
Martí, Ruth1, Author
Pamplona, Reinald1, Author
Brugada, Ramon1, Author
Serena, Joaquin1, Author
Ramió-Torrentà, Lluís1, Author
Coll-De-Tuero, Gabriel1, Author
Gallart, Luís1, Author
Barretina, Jordi1, Author
Vilanova, Joan C1, Author
Mayneris-Perxachs, Jordi1, Author
Saba, Luca1, Author
Pedraza, Salvador1, Author
Kringelbach, Morten L1, Author
Puig, Josep1, AuthorDeco, Gustavo2, Author            more..
Affiliations:
1External Organizations, ou_persistent22              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

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Free keywords: In silico perturbations; Aging; Brain states; Computational modeling; Resting-state fMRI
 Abstract: Understanding the brain changes occurring during aging can provide new insights for developing treatments that alleviate or reverse cognitive decline. Neurostimulation techniques have emerged as potential treatments for brain disorders and to improve cognitive functions. Nevertheless, given the ethical restrictions of neurostimulation approaches, in silico perturbation protocols based on causal whole-brain models are fundamental to gaining a mechanistic understanding of brain dynamics. Furthermore, this strategy could serve to identify neurophysiological biomarkers differentiating between age groups through an exhaustive exploration of the global effect of all possible local perturbations. Here, we used a resting-state fMRI dataset divided into middle-aged (N =310, <65 years) and older adults (N =310, $\geq $65) to characterize brain states in each group as a probabilistic metastable substate (PMS) space. We showed that the older group exhibited a reduced capability to access a metastable substate that overlaps with the rich club. Then, we fitted the PMS to a whole-brain model and applied in silico stimulations in each node to force transitions from the brain states of the older- to the middle-aged group. We found that the precuneus was the best stimulation target. Overall, these findings could have important implications for designing neurostimulation interventions for reversing the effects of aging on whole-brain dynamics.

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Language(s): eng - English
 Dates: 2022-01-312021-11-192022-02-012022-03-21
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1093/cercor/bhac064
Other: online ahead of print
PMID: 35311898
 Degree: -

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Project name : -
Grant ID : 945539
Funding program : Horizon 2020
Funding organization : European Union

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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440