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  The effect of external stimulation on functional networks in the aging healthy human brain

Escrichs, A., Sanz Perl, Y., Martínez-Molina, N., Biarnes, C., Garre-Olmo, J., Fernández-Real, J. M., et al. (2022). The effect of external stimulation on functional networks in the aging healthy human brain. Cerebral Cortex. doi:10.1093/cercor/bhac064.

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Genre: Zeitschriftenartikel

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 Urheber:
Escrichs, Anira1, Autor
Sanz Perl, Yonatan1, Autor
Martínez-Molina, Noelia1, Autor
Biarnes, Carles1, Autor
Garre-Olmo, Josep1, Autor
Fernández-Real, José Manuel1, Autor
Ramos, Rafel1, Autor
Martí, Ruth1, Autor
Pamplona, Reinald1, Autor
Brugada, Ramon1, Autor
Serena, Joaquin1, Autor
Ramió-Torrentà, Lluís1, Autor
Coll-De-Tuero, Gabriel1, Autor
Gallart, Luís1, Autor
Barretina, Jordi1, Autor
Vilanova, Joan C1, Autor
Mayneris-Perxachs, Jordi1, Autor
Saba, Luca1, Autor
Pedraza, Salvador1, Autor
Kringelbach, Morten L1, Autor
Puig, Josep1, AutorDeco, Gustavo2, Autor            mehr..
Affiliations:
1External Organizations, ou_persistent22              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

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Schlagwörter: In silico perturbations; Aging; Brain states; Computational modeling; Resting-state fMRI
 Zusammenfassung: Understanding the brain changes occurring during aging can provide new insights for developing treatments that alleviate or reverse cognitive decline. Neurostimulation techniques have emerged as potential treatments for brain disorders and to improve cognitive functions. Nevertheless, given the ethical restrictions of neurostimulation approaches, in silico perturbation protocols based on causal whole-brain models are fundamental to gaining a mechanistic understanding of brain dynamics. Furthermore, this strategy could serve to identify neurophysiological biomarkers differentiating between age groups through an exhaustive exploration of the global effect of all possible local perturbations. Here, we used a resting-state fMRI dataset divided into middle-aged (N =310, <65 years) and older adults (N =310, $\geq $65) to characterize brain states in each group as a probabilistic metastable substate (PMS) space. We showed that the older group exhibited a reduced capability to access a metastable substate that overlaps with the rich club. Then, we fitted the PMS to a whole-brain model and applied in silico stimulations in each node to force transitions from the brain states of the older- to the middle-aged group. We found that the precuneus was the best stimulation target. Overall, these findings could have important implications for designing neurostimulation interventions for reversing the effects of aging on whole-brain dynamics.

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Sprache(n): eng - English
 Datum: 2022-01-312021-11-192022-02-012022-03-21
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1093/cercor/bhac064
Anderer: online ahead of print
PMID: 35311898
 Art des Abschluß: -

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Projektname : -
Grant ID : 945539
Förderprogramm : Horizon 2020
Förderorganisation : European Union

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Titel: Cerebral Cortex
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York, NY : Oxford University Press
Seiten: - Band / Heft: - Artikelnummer: - Start- / Endseite: - Identifikator: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440