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  Reliability of quantitative multiparameter maps is high for magnetization transfer and proton density but attenuated forR1andR2* in healthy young adults

Wenger, E., Polk, S. E., Kleemeyer, M. M., Weiskopf, N., Bodammer, N. C., Lindenberger, U., et al. (2022). Reliability of quantitative multiparameter maps is high for magnetization transfer and proton density but attenuated forR1andR2* in healthy young adults. Human Brain Mapping. doi:10.1002/hbm.25870.

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 Creators:
Wenger, Elisabeth1, Author
Polk, Sarah E.1, Author
Kleemeyer, Maike M.1, Author
Weiskopf, Nikolaus2, 3, 4, Author              
Bodammer, Nils C.1, Author
Lindenberger, Ulman1, 5, Author
Brandmaier, Andreas M.1, 5, 6, Author
Affiliations:
1Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany, ou_persistent22              
2Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
3Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
4Felix Bloch Institute for Solid State Physics, University of Leipzig, Germany, ou_persistent22              
5Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany, ou_persistent22              
6Department of Psychology, MSB Medical School Berlin, Germany, ou_persistent22              

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Free keywords: MRI; Intraclass correlation effect decomposition; Multiparameter mapping; Reliability
 Abstract: We investigate the reliability of individual differences of four quantities measured by magnetic resonance imaging-based multiparameter mapping (MPM): magnetization transfer saturation (MT), proton density (PD), longitudinal relaxation rate (R1 ), and effective transverse relaxation rate (R2 *). Four MPM datasets, two on each of two consecutive days, were acquired in healthy young adults. On Day 1, no repositioning occurred and on Day 2, participants were repositioned between MPM datasets. Using intraclass correlation effect decomposition (ICED), we assessed the contributions of session-specific, day-specific, and residual sources of measurement error. For whole-brain gray and white matter, all four MPM parameters showed high reproducibility and high reliability, as indexed by the coefficient of variation (CoV) and the intraclass correlation (ICC). However, MT, PD, R1 , and R2 * differed markedly in the extent to which reliability varied across brain regions. MT and PD showed high reliability in almost all regions. In contrast, R1 and R2 * showed low reliability in some regions outside the basal ganglia, such that the sum of the measurement error estimates in our structural equation model was higher than estimates of between-person differences. In addition, in this sample of healthy young adults, the four MPM parameters showed very little variability over four measurements but differed in how well they could assess between-person differences. We conclude that R1 and R2 * might carry only limited person-specific information in some regions of the brain in healthy young adults, and, by implication, might be of restricted utility for studying associations to between-person differences in behavior in those regions.

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Language(s): eng - English
 Dates: 2022-04-09
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/hbm.25870
Other: online ahead of print
PMID: 35397153
 Degree: -

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Project name : -
Grant ID : 203147/Z/16/Z
Funding program : -
Funding organization : Wellcome Centre for Human Neuroimaging
Project name : -
Grant ID : 681094
Funding program : Horizon 2020
Funding organization : European Union
Project name : -
Grant ID : FP7/2007-2013
Funding program : -
Funding organization : European Research Council
Project name : -
Grant ID : 01EW1711A & B, 01GQ1421B
Funding program : -
Funding organization : Bundesministerium für Bildung und Forschung (BMBF)

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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686