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  Combining navigator and optical prospective motion correction for high-quality 500 μm resolution quantitative multi-parameter mapping at 7T

Vaculciakova, L., Podranski, K., Edwards, L., Ocal, D., Veale, T., Fox, N. C., et al. (2022). Combining navigator and optical prospective motion correction for high-quality 500 μm resolution quantitative multi-parameter mapping at 7T. Magnetic Resonance in Medicine, 88(2), 787-801. doi:10.1002/mrm.29253.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000A-61AA-9 Version Permalink: https://hdl.handle.net/21.11116/0000-000E-03CA-B
Genre: Journal Article

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 Creators:
Vaculciakova, Lenka1, Author           
Podranski, Kornelius1, Author           
Edwards, Luke1, Author           
Ocal, Dilek2, Author
Veale, Thomas2, Author
Fox, Nick C.2, Author
Haak, Rainer3, Author
Ehses, Philipp4, Author           
Callaghan, Martina F.5, Author
Pine, Kerrin1, Author           
Weiskopf, Nikolaus1, 5, 6, Author           
Affiliations:
1Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
2Dementia Research Centre, Department of Neurodegenerative Disease, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
3Department of Cariology, Endodontology and Periodontology, University of Leipzig, Germany, ou_persistent22              
4Department of High-field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, ou_persistent22              
5Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
6Felix Bloch Institute for Solid State Physics, University of Leipzig, Germany, ou_persistent22              

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Free keywords: 7T; FID navigator; Multi-parameter mapping; Physiological artifacts; Prospective motion correction; Quantitative MRI
 Abstract: Purpose: High-resolution quantitative multi-parameter mapping shows promise for non-invasively characterizing human brain microstructure but is limited by physiological artifacts. We implemented corrections for rigid head movement and respiration-related B0-fluctuations and evaluated them in healthy volunteers and dementia patients.







Methods: Camera-based optical prospective motion correction (PMC) and FID navigator correction were implemented in a gradient and RF-spoiled multi-echo 3D gradient echo sequence for mapping proton density (PD), longitudinal relaxation rate (R1) and effective transverse relaxation rate (R2*). We studied their effectiveness separately and in concert in young volunteers and then evaluated the navigator correction (NAVcor) with PMC in a group of elderly volunteers and dementia patients. We used spatial homogeneity within white matter (WM) and gray matter (GM) and scan-rescan measures as quality metrics.







Results: NAVcor and PMC reduced artifacts and improved the homogeneity and reproducibility of parameter maps. In elderly participants, NAVcor improved scan-rescan reproducibility of parameter maps (coefficient of variation decreased by 14.7% and 11.9% within WM and GM respectively). Spurious inhomogeneities within WM were reduced more in the elderly than in the young cohort (by 9% vs. 2%). PMC increased regional GM/WM contrast and was especially important in the elderly cohort, which moved twice as much as the young cohort. We did not find a significant interaction between the two corrections.







Conclusion: Navigator correction and PMC significantly improved the quality of PD, R1, and R2* maps, particularly in less compliant elderly volunteers and dementia patients.


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Language(s): eng - English
 Dates: 2022-04-112022-08
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/mrm.29253
Other: epub 2022
PMID: 35405027
 Degree: -

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Project name : -
Grant ID : ARUK-PhD2018-009
Funding program : -
Funding organization : Alzheimer's Research UK
Project name : -
Grant ID : 01EW1711A & B
Funding program : ERA-NET NEURON
Funding organization : -
Project name : -
Grant ID : 616905
Funding program : -
Funding organization : European Research Council (ERC)
Project name : -
Grant ID : 681094
Funding program : Horizon 2020
Funding organization : European Union
Project name : -
Grant ID : 15.0137
Funding program : -
Funding organization : Swiss State Secretariat for Education, Research and Innovation (SERI),
Project name : -
Grant ID : 203147/Z/16/Z
Funding program : -
Funding organization : Wellcome Centre for Human Neuroimaging

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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 88 (2) Sequence Number: - Start / End Page: 787 - 801 Identifier: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149