English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Regulation of neuronal RNA signatures by ELAV/Hu proteins

Hilgers, V. (2022). Regulation of neuronal RNA signatures by ELAV/Hu proteins. Wiley interdisciplinary reviews: WIREs RNA, e1733. doi:10.1002/wrna.1733.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files
hide Files
:
Hilgers 2022.pdf (Publisher version), 2MB
Name:
Hilgers 2022.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
2022
Copyright Info:
The Author

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Hilgers, Valérie1, Author              
Affiliations:
1Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243642              

Content

show
hide
Free keywords: ELAV proteins; RNA; alternative polyadenylation; neuron
 Abstract: The RNA-binding proteins encoded by the highly conserved elav/Hu gene family, found in all metazoans, regulate the expression of a wide range of genes, at both the co-transcriptional and posttranscriptional level. Nervous-system-specific ELAV/Hu proteins are prominent for their essential role in neuron differentiation, and mutations have been associated with human neurodevelopmental and neurodegenerative diseases. Drosophila ELAV, the founding member of the protein family, mediates the synthesis of neuronal RNA signatures by promoting alternative splicing and alternative polyadenylation of hundreds of genes. The recent identification of ELAV's direct RNA targets revealed the protein's central role in shaping the neuronal transcriptome, and highlighted the importance of neuronal transcript signatures for neuron maintenance and organism survival. Animals have evolved multiple cellular mechanisms to ensure robustness of ELAV/Hu function. In Drosophila, elav autoregulates in a 3′UTR-dependent manner to maintain optimal protein levels. A complete absence of ELAV causes the activation and nuclear localization of the normally cytoplasmic paralogue FNE, in a process termed EXon-Activated functional Rescue (EXAR). Other species, including mammals, seem to utilize different strategies, such as protein redundancy, to maintain ELAV protein function and effectively safeguard the identity of the neuronal transcriptome.

Details

show
hide
Language(s): eng - English
 Dates: 2022-04-15
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/wrna.1733
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Wiley interdisciplinary reviews : WIREs RNA
  Other : Wiley Interdiscip Rev RNA
  Abbreviation : WIREs RNA
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Malden, MA, USA : Wiley-Blackwell
Pages: - Volume / Issue: - Sequence Number: e1733 Start / End Page: - Identifier: ISSN: 1757-7012
CoNE: https://pure.mpg.de/cone/journals/resource/1757-7012