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  Stone Age Yersinia pestis genomes shed light on the early evolution, diversity, and ecology of plague

Andrades Valtueña, A., Neumann, G., Spyrou, M. A., Musralina, L., Aron, F., Beisenov, A., et al. (2022). Stone Age Yersinia pestis genomes shed light on the early evolution, diversity, and ecology of plague. Proceedings of the National Academy of Sciences of the United States of America, 119(17): e2116722119, pp. 1-11. doi:10.1073/pnas.2116722119.

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Andrades Valtueña, Aida1, Autor           
Neumann, Gunnar1, Autor           
Spyrou, Maria A., Autor
Musralina, Lyazzat1, Autor           
Aron, Franziska1, Autor           
Beisenov, Arman, Autor
Belinskiy, Andrey B., Autor
Bos, Kirsten I., Autor
Buzhilova, Alexandra, Autor
Conrad, Matthias, Autor
Djansugurova, Leyla B., Autor
Dobes, Miroslav, Autor
Ernee, Michal, Autor
Fernandez-Eraso, Javier, Autor
Frohlich, Bruno, Autor
Furmanek, Mirosław, Autor
Hałuszko, Agata, Autor
Hansen, Svend, Autor
Harney, Eadaoin, Autor
Hiss, Alina N.1, Autor           
Hübner, Alexander, AutorKey, Felix M., AutorKhussainova, Elmira, AutorKitov, Egor, AutorKitova, Alexandra O., AutorKnipper, Corina, AutorKühnert, Denise, AutorLalueza-Fox, Carles, AutorLittleton, Judith, AutorMassy, Ken, AutorMittnik, Alissa, AutorMujika-Alustiza, Jose Antonio, AutorOlalde, Inigo, AutorPapac, Luka1, Autor           Penske, Sandra Ellen1, Autor           Peska, Jaroslav, AutorPinhasi, Ron, AutorReich, David, AutorReinhold, Sabine, AutorStahl, Raphaela1, Autor           Stäuble, Harald, AutorTukhbatova, Rezeda I.1, Autor           Vasilyev, Sergey, AutorVeselovskaya, Elizaveta, AutorWarinner, Christina, AutorStockhammer, Philipp W., AutorHaak, Wolfgang2, Autor           Krause, Johannes2, Autor           Herbig, Alexander2, Autor            mehr..
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              
2tide, Max Planck Institute for the Science of Human History, Max Planck Society, Kahlaische Str. 10, 07745 Jena, DE, ou_2591691              

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Schlagwörter: ancient DNA, plague, Yersinia pestis
 Zusammenfassung: The bacterial pathogen Yersinia pestis gave rise to devastating outbreaks throughout human history, and ancient DNA evidence has shown it afflicted human populations as far back as the Neolithic. Y. pestis genomes recovered from the Eurasian Late Neolithic/Early Bronze Age (LNBA) period have uncovered key evolutionary steps that led to its emergence from a Yersinia pseudotuberculosis-like progenitor; however, the number of reconstructed LNBA genomes are too few to explore its diversity during this critical period of development. Here, we present 17 Y. pestis genomes dating to 5,000 to 2,500 y BP from a wide geographic expanse across Eurasia. This increased dataset enabled us to explore correlations between temporal, geographical, and genetic distance. Our results suggest a nonflea-adapted and potentially extinct single lineage that persisted over millennia without significant parallel diversification, accompanied by rapid dispersal across continents throughout this period, a trend not observed in other pathogens for which ancient genomes are available. A stepwise pattern of gene loss provides further clues on its early evolution and potential adaptation. We also discover the presence of the flea-adapted form of Y. pestis in Bronze Age Iberia, previously only identified in in the Caucasus and the Volga regions, suggesting a much wider geographic spread of this form of Y. pestis. Together, these data reveal the dynamic nature of plague’s formative years in terms of its early evolution and ecology.

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Sprache(n): eng - English
 Datum: 2022-04-262022-04
 Publikationsstatus: Erschienen
 Seiten: 11
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: Results
- Screening and Genome Reconstruction.
- Sixteen Newly Reconstructed Genomes Phylogenetically Placed within the LNBA Lineage.
- First Evidence of Prehistoric Plague on the Iberian Peninsula.
- Temporal Coexistence of Y. pestis Lineages with Different Transmission Potential.
- Genomic Content of Y. pestis During the LNBA Period.
- LNBA Genomes Derive from a Single Lineage.
Discussion
Materials and Methods
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1073/pnas.2116722119
Anderer: shh3196
 Art des Abschluß: -

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Projektname : PALEoRIDER
Grant ID : 771234
Förderprogramm : Horizon 2020 (H2020)
Förderorganisation : European Commission (EC)

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Titel: Proceedings of the National Academy of Sciences of the United States of America
  Andere : PNAS
  Andere : Proceedings of the National Academy of Sciences of the USA
  Kurztitel : Proc. Natl. Acad. Sci. U. S. A.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Washington, D.C. : National Academy of Sciences
Seiten: - Band / Heft: 119 (17) Artikelnummer: e2116722119 Start- / Endseite: 1 - 11 Identifikator: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230