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  ER remodeling via ER-phagy

Gubas, A., & Dikic, I. (2022). ER remodeling via ER-phagy. Molecular Cell, 82(8), 1492-1500. doi:10.1016/j.molcel.2022.02.018.

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 Creators:
Gubas, Andrea1, Author
Dikic, Ivan1, 2, 3, Author                 
Affiliations:
1Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany, ou_persistent22              
2Max Planck Fellow Group ER remodelling Group, Prof. Ivan Đikić, Max Planck Institute of Biophysics, Max Planck Society, ou_3004983              
3Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt, Germany, ou_persistent22              

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 Abstract: The endoplasmic reticulum (ER) is a hotspot for many essential cellular functions. The ER membrane is highly dynamic, which affects many cellular processes that take place within the ER. One such process is ER-phagy, a selective degradation of ER fragments (including membranes and luminal content), which serves to preserve the size of ER while adapting its morphology under basal and stress conditions. In order to be degraded, the ER undergoes selective fragmentation facilitated by specialized ER-shaping proteins that also act as ER-phagy receptors. Their ability to sense and induce membrane curvature, as well as to bridge the ER with autophagy machinery, allows for a successful ER fragmentation and delivery of these fragments to the lysosome for degradation and recycling. In this review, we provide insights into ER-phagy from the perspective of membrane remodeling. We highlight the importance of ER membrane dynamics during ER-phagy and emphasize how its dysregulation reflects on human physiology and pathology.

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Language(s): eng - English
 Dates: 2022-04-212022-04-21
 Publication Status: Issued
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.molcel.2022.02.018
BibTex Citekey: gubas_er_2022
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Title: Molecular Cell
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 82 (8) Sequence Number: - Start / End Page: 1492 - 1500 Identifier: ISSN: 1097-2765
CoNE: https://pure.mpg.de/cone/journals/resource/954925610929