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  An in silico model predicts the impact of scaffold design in large bone defect regeneration

Perier-Metz, C., Cipitria, A., Hutmacher, D. W., Duda, G. N., & Checa, S. (2022). An in silico model predicts the impact of scaffold design in large bone defect regeneration. Acta Biomaterialia, 145, 329-341. doi:10.1016/j.actbio.2022.04.008.

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Perier-Metz, Camille, Author
Cipitria, Amaia1, Author              
Hutmacher, Dietmar W., Author
Duda, Georg N., Author
Checa, Sara, Author
Affiliations:
1Amaia Cipitria, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2489692              

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Free keywords: surface-guided regeneration, scaffold-guided bone regeneration, mechano-biology, in silico modelling, large bone defect healing
 Abstract: Large bone defects represent a clinical challenge for which the implantation of scaffolds appears as a promising strategy. However, their use in clinical routine is limited, in part due to a lack of understanding of how scaffolds should be designed to support regeneration. Here, we use the power of computer modelling to investigate mechano-biological principles behind scaffold-guided bone regeneration and the influence of scaffold design on the regeneration process. Computer model predictions are compared to experimental data of large bone defect regeneration in sheep. We identified two main key players in scaffold-guided regeneration: (1) the scaffold surface guidance of cellular migration and tissue formation processes and (2) the stimulation of progenitor cell activity by the scaffold material composition. In addition, lower scaffold surface-area-to-volume ratio was found to be beneficial for bone regeneration due to enhanced cellular migration. To a lesser extent, a reduced scaffold Young's modulus favoured bone formation. Statement of significance : 3D-printed scaffolds offer promising treatment strategies for large bone defects but their broader clinical use requires a more thorough understanding of their interaction with the bone regeneration process. The predictions of our in silico model compared to two experimental set-ups highlighted the importance of (1) the scaffold surface guidance of cellular migration and tissue formation processes and (2) the scaffold material stimulation of progenitor cell activity. In addition, the model was used to investigate the effect on the bone regeneration process of (1) the scaffold surface-area-to-volume ratio, with lower ratios favouring more bone growth, and (2) the scaffold material properties, with stiffer scaffold materials yielding a lower bone growth.

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Language(s): eng - English
 Dates: 2022-04-102022
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.actbio.2022.04.008
 Degree: -

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Title: Acta Biomaterialia
  Other : Acta Biomater.
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 145 Sequence Number: - Start / End Page: 329 - 341 Identifier: ISSN: 1742-7061