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Abstract:
In a clinical setting, it often has to be decided, which CEST sequences to pick of a collection, due to measurement time limitations. Therefore, eventually not all of the desired contrasts can be measured. In this work, we comprehensively combine seven CEST protocols in a single measurement, use a fast single-shot 3D gradient echo readout and remove redundant regions of the experimental parameter space. Hereby, we can half the total measurement time from 35 to 17 minutes. With further parameter reduction, a total measurement time of 10 minutes is conceivable. This allows to design powerful hypothesis generating clinical pilot studies.
