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  Mitochondrial hitch-hiking of Pink1 mRNA supports axonal mitophagy

Harbauer, A. B., & Schwarz, T. L. (2022). Mitochondrial hitch-hiking of Pink1 mRNA supports axonal mitophagy. Autophagy, 18(12), 3048-3049.

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Harbauer, Angelika B.1, Author           
Schwarz, Thomas L., Author
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1Max Planck Research Group: Neurometabolism / Harbauer, MPI of Neurobiology, Max Planck Society, ou_3232739              

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 Abstract: Mitostasis, the process of mitochondrial maintenance by biogenesis and degradative mechanisms, is challenged by the extreme length of axons. PINK1 (PTEN induced putative kinase 1) is a mitochondrial protein that targets damaged mitochondria for mitophagy. In reconciling the short half-life of PINK1 with the need for mitophagy of damaged axonal mitochondria, we found that axonal mitophagy depends on local translation of the Pink1 mRNA. Using live-cell imaging, we detected co-transport of the Pink1 mRNA on mitochondria in neurons, which is crucial for mitophagy in distal parts of the cell. Here we discuss how the coupling of the transcript of a short-lived mitochondrial protein to the movement of its target organelles contributes to our understanding of mitostasis in neurons.

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 Dates: 2022-12-01
 Publication Status: Issued
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 Identifiers: DOI: 10.1080/15548627.2022.2070332
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Title: Autophagy
Source Genre: Journal
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Publ. Info: Landes Bioscience
Pages: - Volume / Issue: 18 (12) Sequence Number: - Start / End Page: 3048 - 3049 Identifier: ISSN: 1554-8627
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000238500