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  Distinct ensembles in the noradrenergic locus coeruleus are associated with diverse cortical states

Noei, S., Zouridis, I., Logothetis, N., Panzeri, S., & Totah, N. (2022). Distinct ensembles in the noradrenergic locus coeruleus are associated with diverse cortical states. Proceedings of the National Academy of Sciences of the United States of America, 119(18): e2116507119. doi:10.1073/pnas.2116507119.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-000A-615D-1 Versions-Permalink: https://hdl.handle.net/21.11116/0000-000A-615F-F
Genre: Zeitschriftenartikel

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https://www.pnas.org/doi/epdf/10.1073/pnas.2116507119 (Verlagsversion)
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 Urheber:
Noei, S, Autor
Zouridis, IS1, 2, Autor           
Logothetis, NK1, 2, Autor           
Panzeri, S, Autor           
Totah, NK1, 2, Autor           
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Zusammenfassung: SignificanceBrainstem locus coeruleus (LC) noradrenergic neurons produce an arousal-related state characterized by a broadband increase in high-frequency oscillations. This perspective was built upon electrical or optogenetic stimulation that artificially activates LC neurons synchronously. This has led to the conceptual model that LC activation is associated with a single cortical state. Here, we show that natural, spontaneously occurring LC single-unit activity consists of ensembles with largely nonoverlapping activation dynamics. Spontaneous activations of different LC ensembles are associated with different cortical states. Our results suggest that the role of the LC in controlling a single type of cortical state associated with arousal is an oversimplification. Instead, ensembles of LC neurons may control a diverse multitude of cortical states.

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 Datum: 2022-05
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1073/pnas.2116507119
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Titel: Proceedings of the National Academy of Sciences of the United States of America
  Andere : PNAS
  Andere : Proceedings of the National Academy of Sciences of the USA
  Kurztitel : Proc. Natl. Acad. Sci. U. S. A.
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: Washington, D.C. : National Academy of Sciences
Seiten: 12 Band / Heft: 119 (18) Artikelnummer: e2116507119 Start- / Endseite: - Identifikator: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230