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  True-atomic-resolution insights into the structure and functional role of linear chains and low-barrier hydrogen bonds in proteins

Borshchevskiy, V., Kovalev, K., Round, E., Efremov, R., Astashkin, R., Bourenkov, G., et al. (2022). True-atomic-resolution insights into the structure and functional role of linear chains and low-barrier hydrogen bonds in proteins. Nature Structural and Molecular Biology. doi:10.1038/s41594-022-00762-2.

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 Creators:
Borshchevskiy, Valentin1, Author
Kovalev, Kirill1, Author
Round, Ekaterina1, Author
Efremov, Rouslan1, Author
Astashkin, Roman1, Author
Bourenkov, Gleb1, Author
Bratanov, Dmitry1, Author
Balandin, Taras1, Author
Chizhov, Igor1, Author
Baeken, Christian1, Author
Gushchin, Ivan1, Author
Kuzmin, Alexander1, Author
Alekseev, Alexey1, Author
Rogachev, Andrey1, Author
Willbold, Dieter1, Author
Engelhard, Martin1, Author
Bamberg, Ernst2, Author           
Büldt, Georg1, Author
Gordeliy, Valentin1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Emeritusgroup Biophysical Chemistry, Max Planck Institute of Biophysics, Max Planck Society, ou_2253652              

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 Abstract: Hydrogen bonds are fundamental to the structure and function of biological macromolecules and have been explored in detail. The chains of hydrogen bonds (CHBs) and low-barrier hydrogen bonds (LBHBs) were proposed to play essential roles in enzyme catalysis and proton transport. However, high-resolution structural data from CHBs and LBHBs is limited. The challenge is that their 'visualization' requires ultrahigh-resolution structures of the ground and functionally important intermediate states to identify proton translocation events and perform their structural assignment. Our true-atomic-resolution structures of the light-driven proton pump bacteriorhodopsin, a model in studies of proton transport, show that CHBs and LBHBs not only serve as proton pathways, but also are indispensable for long-range communications, signaling and proton storage in proteins. The complete picture of CHBs and LBHBs discloses their multifunctional roles in providing protein functions and presents a consistent picture of proton transport and storage resolving long-standing debates and controversies.

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Language(s): eng - English
 Dates: 2021-11-232022-03-142022-04-28
 Publication Status: Published online
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41594-022-00762-2
BibTex Citekey: borshchevskiy_true-atomic-resolution_2022
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Title: Nature Structural and Molecular Biology
  Other : Nature Struct Biol
Source Genre: Journal
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Publ. Info: New York, NY : Nature Pub. Group
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1545-9993
CoNE: https://pure.mpg.de/cone/journals/resource/954925603763