English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The effect of meninges on the electric fields in TES and TMS: Numerical modeling with adaptive mesh refinement

Weise, K., Wartman, W. A., Knösche, T. R., Nummenmaa, A. R., & Makarov, S. N. (2022). The effect of meninges on the electric fields in TES and TMS: Numerical modeling with adaptive mesh refinement. Brain Stimulation, 15(3), 654-663. doi:10.1016/j.brs.2022.04.009.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files
hide Files
:
Weise_2022.pdf (Publisher version), 6MB
Name:
Weise_2022.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Weise, Konstantin1, 2, Author              
Wartman, William A.3, Author
Knösche, Thomas R.1, 4, Author              
Nummenmaa, Aapo R.3, 5, Author
Makarov, Sergey N.3, 5, Author
Affiliations:
1Methods and Development Group Brain Networks, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205650              
2Department of Advanced Electromagnetics, TU Ilmenau, Germany, ou_persistent22              
3Department of Electrical and Computer Engineering, University of Massachusetts Medical School, Worcester, MA, USA, ou_persistent22              
4Institute for Biomedical Engineering and Informatics, TU Ilmenau, Germany, ou_persistent22              
5Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA, ou_persistent22              

Content

show
hide
Free keywords: Brain stimulation; Electric field; Segmentation; Head modeling; Meninges; Transcranial magnetic stimulation; Transcranial electric stimulation
 Abstract: Background When modeling transcranial electrical stimulation (TES) and transcranial magnetic stimulation (TMS) in the brain, the meninges – dura, arachnoid, and pia mater – are often neglected due to high computational costs. Objective We investigate the impact of the meningeal layers on the cortical electric field in TES and TMS while considering the headreco segmentation as the base model. Method We use T1/T2 MRI data from 16 subjects and apply the boundary element fast multipole method with adaptive mesh refinement, which enables us to accurately solve this problem and establish method convergence at reasonable computational cost. We compare electric fields in the presence and absence of various meninges for two brain areas ( and ) and for several distinct TES and TMS setups. Results Maximum electric fields in the cortex for focal TES consistently increase by approximately 30% on average when the meninges are present in the CSF volume. Their effect on the maximum field can be emulated by reducing the CSF conductivity from 1.65 S/m to approximately 0.85 S/m. In stark contrast to that, the TMS electric fields in the cortex are only weakly affected by the meningeal layers and slightly (∼6%) decrease on average when the meninges are included. Conclusion Our results quantify the influence of the meninges on the cortical TES and TMS electric fields. Both focal TES and TMS results are very consistent. The focal TES results are also in a good agreement with a prior relevant study. The solver and the mesh generator for the meningeal layers (compatible with SimNIBS) are available online.

Details

show
hide
Language(s): eng - English
 Dates: 2022-04-072022-02-012022-04-082022-04-182022-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.brs.2022.04.009
Other: online ahead of print
PMID: 35447379
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : -
Grant ID : WE 5985/1-2
Funding program : -
Funding organization : German Science Foundation (DFG)

Source 1

show
hide
Title: Brain Stimulation
  Abbreviation : Brain Stimul
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Elsevier
Pages: - Volume / Issue: 15 (3) Sequence Number: - Start / End Page: 654 - 663 Identifier: ISSN: 1935-861X
CoNE: https://pure.mpg.de/cone/journals/resource/1935-861X