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  Age-related differences in the neural network interactions underlying the predictability gain

Rysop, A., Schmitt, L., Obleser, J., & Hartwigsen, G. (2022). Age-related differences in the neural network interactions underlying the predictability gain. Cortex. doi:10.1016/j.cortex.2022.05.020.

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 Creators:
Rysop, Anna1, Author              
Schmitt, Lea2, 3, Author
Obleser, Jonas2, 3, Author              
Hartwigsen, Gesa1, Author              
Affiliations:
1Lise Meitner Research Group Cognition and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3025665              
2Department of Psychology, University of Lübeck, Germany, ou_persistent22              
3Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Germany, ou_persistent22              

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Free keywords: Speech in noise; Semantic predictability; Cingulo-opercular network; Effective connectivity; Ageing
 Abstract: Speech comprehension is often challenged by increased background noise, but can be facilitated via the semantic context of a sentence. This predictability gain relies on an interplay of language-specific semantic and domain-general brain regions. However, age-related differences in the interactions within and between semantic and domain-general networks remain poorly understood. Using functional neuroimaging, we investigated commonalities and differences in network interactions enabling processing of degraded speech in healthy young and old participants. Participants performed a sentence repetition task while listening to sentences with high and low predictable endings and varying intelligibility. Stimulus intelligibility was adjusted to individual hearing abilities. Older adults showed an undiminished behavioural predictability gain. Likewise, both groups recruited a similar set of semantic and cingulo-opercular brain regions. However, we observed age-related differences in effective connectivity for high predictable speech of increasing intelligibility. Young adults exhibited stronger connectivity between regions of the cingulo-opercular network and between left insula and the posterior middle temporal gyrus. Moreover, these interactions were excitatory in young adults but inhibitory in old adults. Finally, the degree of the inhibitory influence between cingulo-opercular regions was predictive of the behavioural sensitivity towards changes in intelligibility for high predictable sentences in older adults only. Our results demonstrate that the predictability gain is relatively preserved in older adults when stimulus intelligibility is individually adjusted. While young and old participants recruit similar brain regions, differences manifest in underlying network interactions. Together, these results suggest that ageing affects the network configuration rather than regional activity during successful speech comprehension under challenging listening conditions.

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Language(s): eng - English
 Dates: 2022-03-302021-11-252022-05-032022-06-14
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.cortex.2022.05.020
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Grant ID : HA 6314/4-1, OB 352/2-1
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Funding organization : German Research Foundation (DFG)
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Grant ID : 646696
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Funding organization : European Research Council (ERC)

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Title: Cortex
  Other : Cortex
Source Genre: Journal
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Publ. Info: Milan [etc.] : Elsevier Masson SAS
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0010-9452
CoNE: https://pure.mpg.de/cone/journals/resource/954925393344