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  Sex‐ and age‐specific associations between cardiometabolic risk and white matter brain age in theUKBiobank cohort

Subramaniapillai, S., Suri, S., Barth, C., Maximov, I. I., Voldsbekk, I., Meer, D., et al. (2022). Sex‐ and age‐specific associations between cardiometabolic risk and white matter brain age in theUKBiobank cohort. Human Brain Mapping. doi:10.1002/hbm.25882.

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Subramaniapillai, Sivaniya1, 2, 3, Author
Suri, Sana4, 5, Author
Barth, Claudia6, 7, Author
Maximov, Ivan I.3, 6, 8, Author
Voldsbekk, Irene3, 6, Author
Meer, Dennis6, 9, Author
Gurholt, Tiril P.6, Author
Beck, Dani3, 6, 7, Author
Draganski, Bogdan1, 10, Author              
Andreassen, Ole A.6, 11, Author
Ebmeier, Klaus P.4, Author
Westlye, Lars T.3, 6, 11, Author
Lange, Ann‐Marie G.1, 3, 4, Author
1Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
2Department of Psychology, McGill University, Montréal, QC, Canada, ou_persistent22              
3Department of Psychology, University of Oslo, Norway, ou_persistent22              
4Department of Psychiatry, University of Oxford, United Kingdom, ou_persistent22              
5Wellcome Centre For Integrative Neuroimaging, Oxford Centre for Human Brain Activity (OHBA), University of Oxford, United Kingdom, ou_persistent22              
6NORMENT Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Norway, ou_persistent22              
7Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway, ou_persistent22              
8Department of Health and Functioning, Western Norway University of Applied Sciences, Bergen, Norway, ou_persistent22              
9School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, the Netherlands, ou_persistent22              
10Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
11KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Norway, ou_persistent22              


Free keywords: APOE genetic risk; Brain age; Cardiometabolic health; Menopause; Sex differences
 Abstract: Cardiometabolic risk (CMR) factors are associated with accelerated brain aging and increased risk for sex-dimorphic illnesses such as Alzheimer's disease (AD). Yet, it is unknown how CMRs interact with sex and apolipoprotein E-ϵ4 (APOE4), a known genetic risk factor for AD, to influence brain age across different life stages. Using age prediction based on multi-shell diffusion-weighted imaging data in 21,308 UK Biobank participants, we investigated whether associations between white matter Brain Age Gap (BAG) and body mass index (BMI), waist-to-hip ratio (WHR), body fat percentage (BF%), and APOE4 status varied (i) between males and females, (ii) according to age at menopause in females, and (iii) across different age groups in males and females. We report sex differences in associations between BAG and all three CMRs, with stronger positive associations among males compared to females. Independent of APOE4 status, higher BAG (older brain age relative to chronological age) was associated with greater BMI, WHR, and BF% in males, whereas in females, higher BAG was associated with greater WHR, but not BMI and BF%. These divergent associations were most prominent within the oldest group of females (66-81 years), where greater BF% was linked to lower BAG. Earlier menopause transition was associated with higher BAG, but no interactions were found with CMRs. In conclusion, the findings point to sex- and age-specific associations between CMRs and brain age. Incorporating sex as a factor of interest in studies addressing CMR may promote sex-specific precision medicine, consequently improving health care for both males and females.


Language(s): eng - English
 Dates: 2022-04-23
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/hbm.25882
Other: online ahead of print
PMID: 35460147
 Degree: -



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Project information

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Project name : -
Grant ID : 441
Funding program : -
Funding organization : Alzheimer's Society
Project name : -
Grant ID : 732592, 802998, 847776
Funding program : -
Funding organization : European Research Council
Project name : -
Grant ID : 2017-112, 2018076, 2019-108, 2019101, 2022080
Funding program : -
Funding organization : Helse Sør-Øst RHF
Project name : -
Grant ID : 223273, 249795, 273345, 2837989, 283799, 298646, 300768
Funding program : -
Funding organization : Norges Forskningsråd
Project name : -
Grant ID : 32003B_135679, 32003B_159780, 324730_192755, CRSK- 3_190185, PZ00P3_193658
Funding program : -
Funding organization : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Project name : -
Grant ID : SBF006\1078
Funding program : -
Funding organization : British Heart Foundation
Project name : -
Grant ID : 1117747
Funding program : -
Funding organization : HDH Wills 1965 Charitable Trust
Project name : -
Grant ID : 203139/Z/16/Z
Funding program : -
Funding organization : Wellcome Trust

Source 1

Title: Human Brain Mapping
Source Genre: Journal
Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686