English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs

Olmedo-Suarez, M. A., Ramirez-Diaz, I., Perez-Gonzalez, A., Molina-Herrera, A., Coral-Garcia, M. A., Lobato, S., et al. (2022). Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs. BIOMOLECULES, 12(4): 513. doi:10.3390/biom12040513.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Olmedo-Suarez, Miguel Angel, Author
Ramirez-Diaz, Ivonne, Author
Perez-Gonzalez, Andrea, Author
Molina-Herrera, Alejandro, Author
Coral-Garcia, Miguel Angel, Author
Lobato, Sagrario, Author
Sarvari, Pouya1, Author              
Barreto, Guillermo2, Author              
Rubio, Karla2, Author              
Affiliations:
1Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Max Planck Society, ou_2591698              
2Lung Cancer Epigenetics, Max Planck Institute for Heart and Lung Research, Max Planck Society, ou_2591699              

Content

show
hide
Free keywords: -
 Abstract: Environmental factors, including pollutants and lifestyle, constitute a significant role in severe, chronic pathologies with an essential societal, economic burden. The measurement of all environmental exposures and assessing their correlation with effects on individual health is defined as the exposome, which interacts with our unique characteristics such as genetics, physiology, and epigenetics. Epigenetics investigates modifications in the expression of genes that do not depend on the underlying DNA sequence. Some studies have confirmed that environmental factors may promote disease in individuals or subsequent progeny through epigenetic alterations. Variations in the epigenetic machinery cause a spectrum of different disorders since these mechanisms are more sensitive to the environment than the genome, due to the inherent reversible nature of the epigenetic landscape. Several epigenetic mechanisms, including modifications in DNA (e.g., methylation), histones, and noncoding RNAs can change genome expression under the exogenous influence. Notably, the role of long noncoding RNAs in epigenetic processes has not been well explored in the context of exposome-induced tumorigenesis. In the present review, our scope is to provide relevant evidence indicating that epigenetic alterations mediate those detrimental effects caused by exposure to environmental toxicants, focusing mainly on a multi-step regulation by diverse noncoding RNAs subtypes.

Details

show
hide
Language(s):
 Dates: 2022-03-28
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000786359200001
DOI: 10.3390/biom12040513
PMID: 35454102
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: BIOMOLECULES
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 12 (4) Sequence Number: 513 Start / End Page: - Identifier: -