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  Investigating the Anatomy and Microstructure of the Dentato-rubro-thalamic and Subthalamo-ponto-cerebellar Tracts in Parkinson's Disease

Lipp, I., Mole, J. P., Subramanian, L., Linden, D. E. J., & Metzler-Baddeley, C. (2022). Investigating the Anatomy and Microstructure of the Dentato-rubro-thalamic and Subthalamo-ponto-cerebellar Tracts in Parkinson's Disease. Frontiers in Neurology, 13: 793693. doi:10.3389/fneur.2022.793693.

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 Creators:
Lipp, Ilona1, 2, 3, Author              
Mole, Jilu Princy1, 2, 3, Author
Subramanian, Leena1, 2, Author
Linden, David E. J.1, 2, 4, 5, Author
Metzler-Baddeley, Claudia1, 4, Author
Affiliations:
1Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, United Kingdom, ou_persistent22              
2Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, United Kingdom, ou_persistent22              
3Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
4Neuroscience and Mental Health Research Institute, Cardiff University, United Kingdom, ou_persistent22              
5School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, the Netherlands, ou_persistent22              

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Free keywords: Parkinson's disease; Basal ganglia; Cerebellum; Cortico-cerebellar pathways; Dentato-rubro-thalamic tract; Diffusion tractography; Microstructure; Subthalamo-ponto-cerebellar tract
 Abstract: Cerebellar-thalamic connections play a central role in deep brain stimulation-based treatment of tremor syndromes. Here, we used diffusion Magnetic Resonance Imaging (MRI) tractography to delineate the main cerebellar peduncles as well as two main white matter tracts that connect the cerebellum with the thalamus, the dentato-rubro-thalamic tract (DRTT) and the subthalamo-ponto-cerebellar tract (SPCT). We first developed a reconstruction protocol in young healthy adults with high-resolution diffusion imaging data and then demonstrate feasibility of transferring this protocol to clinical studies using standard diffusion MRI data from a cohort of patients with Parkinson's disease (PD) and their matched healthy controls. The tracts obtained closely corresponded to the previously described anatomical pathways and features of the DRTT and the SPCT. Second, we investigated the microstructure of these tracts with fractional anisotropy (FA), radial diffusivity (RD), and hindrance modulated orientational anisotropy (HMOA) in patients with PD and healthy controls. By reducing dimensionality of both the microstructural metrics and the investigated cerebellar and cerebellar-thalamic tracts using principal component analyses, we found global differences between patients with PD and controls, suggestive of higher fractional anisotropy, lower radial diffusivity, and higher hindrance modulated orientational anisotropy in patients. However, separate analyses for each of the tracts did not yield any significant differences. Our findings contribute to the characterization of the distinct anatomical connections between the cerebellum and the diencephalon. Microstructural differences between patients and controls in the cerebellar pathways suggest involvement of these structures in PD, complementing previous functional and diffusion imaging studies.

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Language(s): eng - English
 Dates: 2021-10-122022-02-072022-03-24
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3389/fneur.2022.793693
Other: eCollection 2022
PMID: 35401393
PMC: PMC8987292
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Grant ID : 502341
Funding program : -
Funding organization : Wellcome Trust
Project name : -
Grant ID : 208
Funding program : -
Funding organization : Alzheimer's Society

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Title: Frontiers in Neurology
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 13 Sequence Number: 793693 Start / End Page: - Identifier: ISSN: 1664-2295
CoNE: https://pure.mpg.de/cone/journals/resource/1664-2295