English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Microbiota alterations in proline metabolism impact depression

Mayneris-Perxachs, J., Castells-Nobau, A., Arnoriaga-Rodríguez, M., Martin, M., de la Vega-Correa, L., Zapata, C., et al. (2022). Microbiota alterations in proline metabolism impact depression. Cell Metabolism, 34(5), 681-701.e10. doi:10.1016/j.cmet.2022.04.001.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files
hide Files
:
Mayneris_2022.pdf (Publisher version), 9MB
Name:
Mayneris_2022.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Mayneris-Perxachs, Jordi1, Author
Castells-Nobau, Anna1, Author
Arnoriaga-Rodríguez, María1, Author
Martin, Miquel1, Author
de la Vega-Correa, Lisset1, Author
Zapata, Cristina1, Author
Burokas, Aurelijus1, Author
Blasco, Gerard1, Author
Coll, Clàudia1, Author
Escrichs, Anira1, Author
Biarnés, Carles1, Author
Moreno-Navarrete, José María1, Author
Puig, Josep1, Author
Garre-Olmo, Josep1, Author
Ramos, Rafel1, Author
Pedraza, Salvador1, Author
Brugada, Ramón1, Author
Vilanova, Joan Carles1, Author
Serena, Joaquín1, Author
Gich, Jordi1, Author
Ramió-Torrentà, Lluís1, AuthorPérez-Brocal, Vicente1, AuthorMoya, Andrés1, AuthorPamplona, Reinald1, AuthorSol, Joaquim1, AuthorJové, Mariona1, AuthorRicart, Wifredo1, AuthorPortero-Otin, Manuel1, AuthorDeco, Gustavo2, Author              Maldonado, Rafael1, AuthorFernández-Real, José Manuel1, Author more..
Affiliations:
1External Organizations, ou_persistent22              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

Content

show
hide
Free keywords: Amino acids; Brain; Cognition; Depression; Diet; Gut microbiota; Proline
 Abstract: The microbiota-gut-brain axis has emerged as a novel target in depression, a disorder with low treatment efficacy. However, the field is dominated by underpowered studies focusing on major depression not addressing microbiome functionality, compositional nature, or confounding factors. We applied a multi-omics approach combining pre-clinical models with three human cohorts including patients with mild depression. Microbial functions and metabolites converging onto glutamate/GABA metabolism, particularly proline, were linked to depression. High proline consumption was the dietary factor with the strongest impact on depression. Whole-brain dynamics revealed rich club network disruptions associated with depression and circulating proline. Proline supplementation in mice exacerbated depression along with microbial translocation. Human microbiota transplantation induced an emotionally impaired phenotype in mice and alterations in GABA-, proline-, and extracellular matrix-related prefrontal cortex genes. RNAi-mediated knockdown of proline and GABA transporters in Drosophila and mono-association with L. plantarum, a high GABA producer, conferred protection against depression-like states. Targeting the microbiome and dietary proline may open new windows for efficient depression treatment.

Details

show
hide
Language(s): eng - English
 Dates: 2022-01-312021-05-062022-04-042022-05-032022-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.cmet.2022.04.001
PMID: 35508109
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : -
Grant ID : PI20/01090, PI15/01934, PI18/01022, and PI21/01361
Funding program : -
Funding organization : Instituto de Salud Carlos III
Project name : -
Grant ID : 2017SGR696
Funding program : -
Funding organization : Generalitat of Catalonia

Source 1

show
hide
Title: Cell Metabolism
  Other : Cell Metabolism
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Cambridge, MA : Cell Press
Pages: - Volume / Issue: 34 (5) Sequence Number: - Start / End Page: 681 - 701.e10 Identifier: ISSN: 1550-4131
CoNE: https://pure.mpg.de/cone/journals/resource/111088195284928