English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Loss-of-function mutations in the melanocortin 1 receptor cause disruption of dorso-ventral countershading in teleost fish

Cal, L., Suarez-Bregua, P., Braasch, I., Irion, U., Kelsh, R., Cerdá-Reverter, J., et al. (2019). Loss-of-function mutations in the melanocortin 1 receptor cause disruption of dorso-ventral countershading in teleost fish. Pigment Cell & Melanoma Research, 32(6), 817-828. doi:10.1111/pcmr.12806.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Cal, L, Author
Suarez-Bregua, P, Author
Braasch, I, Author
Irion, U1, Author           
Kelsh, R, Author
Cerdá-Reverter, JM, Author
Rotllant, J, Author
Affiliations:
1Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3375716              

Content

show
hide
Free keywords: -
 Abstract: The melanocortin 1 receptor (MC1R) is the central melanocortin receptor involved in vertebrate pigmentation. Mutations in this gene cause variations in coat coloration in amniotes. Additionally, in mammals MC1R is the main receptor for agouti-signaling protein (ASIP), making it the critical receptor for the establishment of dorsal-ventral countershading. In fish, Mc1r is also involved in pigmentation, but it has been almost exclusively studied in relation to melanosome dispersion activity and as a putative genetic factor involved in dark/light adaptation. However, its role as the crucial component for the Asip1-dependent control of dorsal-ventral pigmentation remains unexplored. Using CRISPR/Cas9, we created mc1r homozygous knockout zebrafish and found that loss-of-function of mc1r causes a reduction of countershading and a general paling of the animals. We find ectopic development of melanophores and xanthophores, accompanied by a decrease in iridophore numbers in the ventral region of mc1r mutants. We also reveal subtle differences in the role of mc1r in repressing pigment cell development between the skin and scale niches in ventral regions.

Details

show
hide
Language(s):
 Dates: 2019-11
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1111/pcmr.12806
PMID: 31251842
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Pigment Cell & Melanoma Research
  Other : (Formerly: Pigment Cell Research)
  Abbreviation : Pigment Cell Melanoma Res.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Oxford : Wiley-Blackwell
Pages: - Volume / Issue: 32 (6) Sequence Number: - Start / End Page: 817 - 828 Identifier: ISSN: 1600-0749
ISSN: 0893-5785
CoNE: https://pure.mpg.de/cone/journals/resource/pigmentcellres