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  Adaptation to sub-optimal hosts is a driver of viral diversification in the ocean

Enav, H., Kirzer, S., Lindell, D., Mandel-Gutfreund, Y., & Béjà, o. (2018). Adaptation to sub-optimal hosts is a driver of viral diversification in the ocean. Nature Communications, 9: 4698. doi:10.1038/s41467-018-07164-3.

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Enav, H1, Author           
Kirzer, S, Author
Lindell, D, Author
Mandel-Gutfreund, Y, Author
Béjà, o, Author
Affiliations:
1Department Microbiome Science, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3375789              

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 Abstract: Cyanophages of the Myoviridae family include generalist viruses capable of infecting a wide range of hosts including those from different cyanobacterial genera. While the influence of phages on host evolution has been studied previously, it is not known how the infection of distinct hosts influences the evolution of cyanophage populations. Here, using an experimental evolution approach, we investigated the adaptation of multiple cyanophage populations to distinct cyanobacterial hosts. We show that when infecting an "optimal" host, whose infection is the most efficient, phage populations accumulated only a few mutations. However, when infecting "sub-optimal" hosts, different mutations spread in the phage populations, leading to rapid diversification into distinct subpopulations. Based on our results, we propose a model demonstrating how shifts in microbial abundance, which lead to infection of "sub-optimal" hosts, act as a driver for rapid diversification of viral populations.

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 Dates: 2018-11
 Publication Status: Issued
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 Identifiers: DOI: 10.1038/s41467-018-07164-3
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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: 11 Volume / Issue: 9 Sequence Number: 4698 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723