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  Spherulitic crystal growth drives mineral deposition patterns in collagen-based materials

Macías-Sánchez, E., Tarakina, N. V., Ivanov, D., Blouin, S., Berzlanovich, A. M., & Fratzl, P. (2022). Spherulitic crystal growth drives mineral deposition patterns in collagen-based materials. Advanced Functional Materials, 2200504. doi:10.1002/adfm.202200504.

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Genre: Journal Article

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 Creators:
Macías-Sánchez, Elena1, Author              
Tarakina, Nadezda V.2, Author              
Ivanov, Danail, Author
Blouin, Stéphane, Author
Berzlanovich, Andrea M., Author
Fratzl, Peter3, Author              
Affiliations:
1Luca Bertinetti, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2379691              
2Nadezda V. Tarakina, Kolloidchemie, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2522693              
3Peter Fratzl, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863294              

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Free keywords: 3D electron microscopy; bone mineralization; collagen mineralization; energy dispersive X-ray spectroscopy; transmission electron microscopy
 Abstract: The formation of the hard tissues that provide support and mobility to organisms is achieved through the interplay of inorganic crystals and an organic framework composed of collagen and a small percentage of non-collagenous proteins. Despite their clinical relevance, the mechanisms governing mineralization of the extracellular matrix are still poorly understood. By using 3D electron tomography and high-resolution electron microscopy imaging and spectroscopy, it has been demonstrated that mineralization proceeds through a spherulitic-like crystal growth process. First, aggregates of disordered crystals form in the interfibrillar spaces, which lead to the mineralization of adjacent fibrils. Mineral propagates steadily through the inter- and intrafibrillar spaces of the collagen structure forming layered spherulites that grow to confluence. The structure of the collagen fibrils serves as a protein scaffold to guide the formation of a myriad of platelet-shaped crystallites that make up each of these spherulites. At their periphery, nanosized unmineralized areas remain, leading to the formation of the characteristic lacy pattern observed in the transversal cross-section of mature calcified tissues. This study provides fundamental insights into the bone formation process and represents a potential strategy for complex materials design.

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Language(s): eng - English
 Dates: 2022-05-12
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/adfm.202200504
PMID: 0629
 Degree: -

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Title: Advanced Functional Materials
  Abbreviation : Adv. Funct. Mater.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH Verlag GmbH
Pages: - Volume / Issue: - Sequence Number: 2200504 Start / End Page: - Identifier: ISSN: 1616-301X