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  A whole-brain connectivity map of mouse insular cortex

Gehrlach, D. A., Gaitanos, T. N., Klein, A. S., Weiand, C., Hennrich, A. A., Conzelmann, K.-K., et al. (2020). A whole-brain connectivity map of mouse insular cortex. eLife, 9: e55585. doi:10.7554/eLife.55585.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000A-7A18-3 Version Permalink: https://hdl.handle.net/21.11116/0000-000A-7A19-2
Genre: Journal Article

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© 2020, Gehrlach et al.
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 Creators:
Gehrlach, Daniel A.1, Author           
Gaitanos, Thomas N.1, Author           
Klein, Alexandra S.1, Author           
Weiand, Caroline1, Author           
Hennrich, Alexandru A., Author
Conzelmann, Karl-Klaus, Author
Gogolla, Nadine1, Author           
Affiliations:
1Max Planck Research Group: Circuits for Emotion / Gogolla, MPI of Neurobiology, Max Planck Society, ou_2054290              

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 Abstract: The insular cortex (IC) plays key roles in emotional and regulatory brain functions and is affected across psychiatric diseases. However, the brain-wide connections of the mouse IC have not been comprehensively mapped. Here we traced the whole-brain inputs and outputs of the mouse IC across its rostro-caudal extent. We employed cell-type specific monosynaptic rabies virus tracings to characterize afferent connections onto either excitatory or inhibitory IC neurons, and adeno-associated viral tracings to label excitatory efferent axons. While the connectivity between the IC and other cortical regions was highly reciprocal, the IC connectivity with subcortical structures was often unidirectional, revealing prominent top-down and bottom-up pathways. The posterior and medial IC exhibited resembling connectivity patterns, while the anterior IC connectivity was distinct, suggesting two major functional compartments. Our results provide insights into the anatomical architecture of the mouse IC and thus a structural basis to guide investigations into its complex functions.

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 Dates: 2020-09-17
 Publication Status: Issued
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 Rev. Type: Peer
 Identifiers: DOI: 10.7554/eLife.55585
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Project name : Deutsche Forschungsgemeinschaft (SPP1665 to K.-K.C., D.A.G. and N.G.)
Grant ID : -
Funding program : (SPP1665)
Funding organization : Deutsche Forschungsgemeinschaft
Project name : European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (ERC-2017-STG, grant agreement 758448 to N.G.)
Grant ID : 758448
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)
Project name : ANR-DFG project ‘SAFENET’ (ANR-17-CE37-0021 to A.K. and N.G.)
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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 9 Sequence Number: e55585 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X