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  DNA methylation: a historical perspective

Mattei, A. L., Bailly, N., & Meissner, A. (2022). DNA methylation: a historical perspective. Trends in Genetics. doi:10.1016/j.tig.2022.03.010.

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TiG_Mattei et al_2022.pdf (Publisher version), 6MB
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© 2022 The Authors

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 Creators:
Mattei, Alexandra L.1, Author              
Bailly, Nina1, Author              
Meissner, Alexander1, Author              
Affiliations:
1Dept. of Genome Regulation (Head: Alexander Meissner), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_2379694              

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Free keywords: DNA methylation epigenetics 5-methylcytosine development gene regulation
 Abstract: In 1925, 5-methylcytosine was first reported in bacteria. However, its biological importance was not intuitive for several decades. After this initial lag, the ubiquitous presence of this methylated base emerged across all domains of life and revealed a range of essential biological functions. Today, we are armed with the knowledge of the key factors that establish, maintain, and remove DNA methylation and have access to a staggering and rapidly growing number of base-resolution methylation maps. Despite this, several fundamental details about the precise role and interpretation of DNA methylation patterns remain under investigation. Here, we review the field of DNA methylation from its beginning to present day, with an emphasis on findings in mammalian systems, and point the reader to select experiments that form the foundation of this field.

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Language(s): eng - English
 Dates: 2022-04-30
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.tig.2022.03.010
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Title: Trends in Genetics
  Other : Trends Genet.
Source Genre: Journal
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Publ. Info: Elsevier Current Trends
Pages: 32 Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0168-9525
CoNE: https://pure.mpg.de/cone/journals/resource/954925485719